Document Detail

Central basis of muscle fatigue in chronic fatigue syndrome.
MedLine Citation:
PMID:  8423875     Owner:  NLM     Status:  MEDLINE    
We studied whether muscle fatigue, metabolism, or activation are abnormal in the chronic fatigue syndrome (CFS). Subjects performed both an intermittent submaximal and a sustained maximal voluntary isometric exercise protocol of the tibialis anterior muscle. The extent of fatigue, metabolic response, and changes in both M-wave amplitude and twitch tension during exercise were similar in patients and controls. The response to systemic exercise was also normal in the patients. However, voluntary activation of the tibialis was significantly lower in the patients during maximal sustained exercise. The results indicate that patients with CFS have (1) normal fatigability and metabolism at both the intracellular and systemic levels, (2) normal muscle membrane function and excitation-contraction coupling, and (3) an inability to fully activate skeletal muscle during intense, sustained exercise. This failure of activation was well in excess of that found in controls, suggesting an important central component of muscle fatigue in CFS.
J A Kent-Braun; K R Sharma; M W Weiner; B Massie; R G Miller
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurology     Volume:  43     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-02-23     Completed Date:  1993-02-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  125-31     Citation Subset:  AIM; IM    
Department of Neurology, University of California, San Francisco.
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MeSH Terms
Exercise / physiology
Fatigue Syndrome, Chronic / etiology*,  physiopathology
Isometric Contraction / physiology
Lactates / blood
Muscle Contraction / physiology*
Muscles / metabolism
Reg. No./Substance:
Comment In:
Neurology. 1993 Sep;43(9):1866-7   [PMID:  8414064 ]

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