Document Detail

Central application of a nitric oxide donor activates heat defense in the rabbit.
MedLine Citation:
PMID:  9452224     Owner:  NLM     Status:  MEDLINE    
In chronically instrumented, conscious rabbits at moderately warm ambient thermal conditions, infusion of the NO-donor SIN-1 into the anterio-ventral 3rd cerebral ventricle (1-2 microg/min per kg BW, 2-4 microl/min, 30 min) initiated a co-ordinated activation of autonomic heat loss mechanisms, as indicated by the rise in ear skin temperature and by increases in panting frequency and respiratory evaporative water loss, while oxygen consumption decreased slightly. The heat loss responses were similar to those attributed to NO in studies employing systemic application of NO-donors. Different from NO acting peripherally, which causes arterial hypotension and tachycardia, centrally acting NO induced arterial hypertension and bradycardia. The observation of the same heat loss responses despite opposing circulatory actions suggests that NO is specifically involved in thermoregulation as a central activator of heat defense mechanisms.
S Eriksson; H Hjelmqvist; R Keil; R Gerstberger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research     Volume:  774     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-03-11     Completed Date:  1998-03-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  269-73     Citation Subset:  IM    
Max-Planck-Institute for Physiological and Clinical Research, W.G. Kerckhoff-Institute, Bad Nauheim, Germany.
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MeSH Terms
Blood Pressure / drug effects
Body Temperature / drug effects
Body Temperature Regulation / drug effects*,  physiology*
Brain / physiology*
Ear / physiology
Heart Rate / drug effects
Hot Temperature*
Hybridization, Genetic
Injections, Intraventricular
Molsidomine / analogs & derivatives*,  pharmacology
Nitric Oxide / physiology*
Oxygen Consumption / drug effects
Respiration / drug effects
Skin Temperature / drug effects
Water Loss, Insensible / drug effects
Reg. No./Substance:
10102-43-9/Nitric Oxide; 25717-80-0/Molsidomine; 33876-97-0/3-morpholino-sydnonimine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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