Document Detail

Central aortic pressure is independently associated with diastolic function.
MedLine Citation:
PMID:  20569723     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Studies investigating the association between central aortic pressures and diastolic function have been limited.
METHODS: Consecutive ambulatory patients (n = 281, mean age 49 +/- 13 years, 49% male) with normal left ventricular (LV) systolic function were included. The LV filling pressure (E/Em) was estimated by Doppler-derived ratio of mitral inflow velocity (E) to septal (Em) by tissue Doppler, LV relaxation by Em, and central aortic pressures by radial tonometry. Central aortic systolic (cSBP), diastolic (cDBP), mean (cMAP) and pulse pressure (cPP) were entered individually into stepwise linear regression models to determine their association with E/Em or Em.
RESULTS: In univariate analysis, cPP correlated most strongly with E/Em (Spearman's rho = 0.45, P < .001), whereas cSBP correlated most strongly with Em (Spearman's rho = -0.51, P < .001). Multivariate analysis demonstrated that the pulsatile component of afterload, cPP, contributed most to E/Em (partial r(2) = 23%); meanwhile, the nonpulsatile components (cDBP and cMAP) were significant but small contributors (partial r(2) of 6% and 5%, respectively) of LV relaxation (Em).
CONCLUSION: The nonpulsatile components of aortic afterload (cMAP and cDBP) exhibited a weak but significant association with LV relaxation, whereas the pulsatile component of afterload, cPP, exhibited strong association with LV filling pressure.
Sumeet Subherwal; Lisa de las Fuentes; Alan D Waggoner; Sharon Heuerman; Karen E Spence; Victor G Davila-Roman
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  159     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-23     Completed Date:  2010-07-15     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1081-8     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 Mosby, Inc. All rights reserved.
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MeSH Terms
Aorta / physiology*
Blood Pressure / physiology*
Blood Pressure Determination / methods
Echocardiography, Doppler
Heart Ventricles / ultrasonography
Middle Aged
Reproducibility of Results
Ventricular Function, Left / physiology*
Ventricular Pressure / physiology
Grant Support
K12 RR023249/RR/NCRR NIH HHS; K12 RR023249-03/RR/NCRR NIH HHS; KL2 RR024994/RR/NCRR NIH HHS; KL2 RR024994-03/RR/NCRR NIH HHS; L30 HL074749/HL/NHLBI NIH HHS; L30 HL074749-03/HL/NHLBI NIH HHS; M01 RR000036-47/RR/NCRR NIH HHS; R01 HL071782-01A1/HL/NHLBI NIH HHS; R01 HL071782-02/HL/NHLBI NIH HHS; R01 HL071782-03/HL/NHLBI NIH HHS; R01 HL071782-04/HL/NHLBI NIH HHS; R01 HL071782-05A1/HL/NHLBI NIH HHS; R01 HL071782-06/HL/NHLBI NIH HHS; R21 HL094668/HL/NHLBI NIH HHS; R21 HL094668-02/HL/NHLBI NIH HHS; S10 RR014778-01/RR/NCRR NIH HHS; S10 RR014778-018104/RR/NCRR NIH HHS; UL1 RR024992/RR/NCRR NIH HHS; UL1 RR024992-03/RR/NCRR NIH HHS

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