| Central angiotensin II-induced pressor responses and neural activity in utero and hypothalamic angiotensin receptors in preterm ovine fetus. | |
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MedLine Citation:
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PMID: 14684369 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The central renin-angiotensin system is important in the control of blood pressure in the adult. However, few data exist about the in utero development of central angiotensin-mediated pressor responses. Our recent studies have shown that the application of ANG II into the fetal brain can increase blood pressure at near term. The present study determined fetal blood pressure and heart rate in response to a central application of ANG II in the chronically prepared preterm ovine fetus, determined the action sites marked by c-Fos expression in the fetal central pathways after intracerebroventricular injection of ANG II in utero, and determined angiotensin subtype 1 receptors in the fetal hypothalamus. Central injection of ANG II significantly increased fetal mean arterial pressure (MAP). Adjusted fetal MAP against amniotic pressure was also increased by ANG II. Fetal heart rate was subsequently decreased after the central administration of ANG II and/or the increase of blood pressure. ANG II induced c-Fos expression in the central putative cardiovascular area, the paraventricular nuclei in the brain sympathetic pathway. Application of ANG II also caused intense Fos immunoreactivity in the tractus solitarius nuclei in the hindbrain. In addition, intense angiotensin subtype 1 receptors were expressed in the hypothalamus at preterm. These data demonstrate that central ANG II-related pressor centers start to function as early as at preterm and suggest that the central angiotensin-related sympathetic pathway is likely intact in the control of blood pressure in utero. |
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Authors:
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Zhice Xu; Lijun Shi; Jiaming Yao |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2003-12-18 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 286 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-03-15 Completed Date: 2004-04-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H1507-14 Citation Subset: IM |
Affiliation:
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Harbor-University of California Los Angeles Medical Center, (UCLA), Harbor-UCLA Medical Center, Torrance, CA 90502, USA. zxu@gcrc.rei.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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administration & dosage,
pharmacology* Animals Blood Pressure / drug effects* Female Fetus / physiology* Genes, fos / genetics Heart Rate, Fetal / drug effects Hemodynamics / physiology Hypothalamus / drug effects* Immunohistochemistry Injections, Intraventricular Neural Pathways / embryology, physiology Neurons / drug effects* Pregnancy Receptors, Angiotensin / metabolism* Renin-Angiotensin System / physiology Sheep Vasoconstrictor Agents / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Angiotensin; 0/Vasoconstrictor Agents; 11128-99-7/Angiotensin II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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