| Central angiotensin II has catabolic action at white and brown adipose tissue. | |
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MedLine Citation:
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PMID: 21862725 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Considerable evidence implicates the renin-angiotensin system (RAS) in the regulation of energy balance. To evaluate the role of the RAS in the central nervous system regulation of energy balance, we used osmotic minipumps to chronically administer angiotensin II (Ang II; icv; 0.7 ng/min for 24 days) to adult male Long-Evans rats, resulting in reduced food intake, body weight gain, and adiposity. The decrease in body weight and adiposity occurred relative to both ad libitum- and pair-fed controls, implying that reduced food intake in and of itself does not underlie all of these effects. Consistent with this, rats administered Ang II had increased whole body heat production and oxygen consumption. Additionally, chronic icv Ang II increased uncoupling protein-1 and β(3)-adrenergic receptor expression in brown adipose tissue and β3-adrenergic receptor expression in white adipose tissue, which is suggestive of enhanced sympathetic activation and thermogenesis. Chronic icv Ang II also increased hypothalamic agouti-related peptide and decreased hypothalamic proopiomelanocortin expression, consistent with a state of energy deficit. Moreover, chronic icv Ang II increased the anorectic corticotrophin- and thyroid-releasing hormones within the hypothalamus. These results suggest that Ang II acts in the brain to promote negative energy balance and that contributing mechanisms include an alteration in the hypothalamic circuits regulating energy balance, a decrease in food intake, an increase in energy expenditure, and an increase in sympathetic activation of brown and white adipose tissue. |
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Authors:
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Annette D de Kloet; Eric G Krause; Karen A Scott; Michelle T Foster; James P Herman; Randall R Sakai; Randy J Seeley; Stephen C Woods |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2011-08-23 |
Journal Detail:
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Title: American journal of physiology. Endocrinology and metabolism Volume: 301 ISSN: 1522-1555 ISO Abbreviation: Am. J. Physiol. Endocrinol. Metab. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-11-30 Completed Date: 2012-01-23 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: E1081-91 Citation Subset: IM |
Affiliation:
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Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, Florida 32611, USA. adekloet@ufl.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue, Brown
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drug effects*,
metabolism Adipose Tissue, White / drug effects*, metabolism Angiotensin II / administration & dosage*, pharmacology* Animals Body Weight / drug effects Brain / drug effects* Dose-Response Relationship, Drug Down-Regulation / drug effects Drug Evaluation, Preclinical Eating / drug effects Infusion Pumps, Implantable Infusions, Intraventricular Infusions, Subcutaneous Male Metabolism / drug effects Rats Rats, Long-Evans |
| Grant Support | |
ID/Acronym/Agency:
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DK-017844/DK/NIDDK NIH HHS; DK-056863/DK/NIDDK NIH HHS; DK-078201/DK/NIDDK NIH HHS; DK-087816/DK/NIDDK NIH HHS; DK-54890/DK/NIDDK NIH HHS; HL-096830/HL/NHLBI NIH HHS; NS-681222/NS/NINDS NIH HHS; R00 HL096830/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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11128-99-7/Angiotensin II |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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