Document Detail


Central angiotensin II has catabolic action at white and brown adipose tissue.
MedLine Citation:
PMID:  21862725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Considerable evidence implicates the renin-angiotensin system (RAS) in the regulation of energy balance. To evaluate the role of the RAS in the central nervous system regulation of energy balance, we used osmotic minipumps to chronically administer angiotensin II (Ang II; icv; 0.7 ng/min for 24 days) to adult male Long-Evans rats, resulting in reduced food intake, body weight gain, and adiposity. The decrease in body weight and adiposity occurred relative to both ad libitum- and pair-fed controls, implying that reduced food intake in and of itself does not underlie all of these effects. Consistent with this, rats administered Ang II had increased whole body heat production and oxygen consumption. Additionally, chronic icv Ang II increased uncoupling protein-1 and β(3)-adrenergic receptor expression in brown adipose tissue and β3-adrenergic receptor expression in white adipose tissue, which is suggestive of enhanced sympathetic activation and thermogenesis. Chronic icv Ang II also increased hypothalamic agouti-related peptide and decreased hypothalamic proopiomelanocortin expression, consistent with a state of energy deficit. Moreover, chronic icv Ang II increased the anorectic corticotrophin- and thyroid-releasing hormones within the hypothalamus. These results suggest that Ang II acts in the brain to promote negative energy balance and that contributing mechanisms include an alteration in the hypothalamic circuits regulating energy balance, a decrease in food intake, an increase in energy expenditure, and an increase in sympathetic activation of brown and white adipose tissue.
Authors:
Annette D de Kloet; Eric G Krause; Karen A Scott; Michelle T Foster; James P Herman; Randall R Sakai; Randy J Seeley; Stephen C Woods
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2011-08-23
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  301     ISSN:  1522-1555     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-30     Completed Date:  2012-01-23     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E1081-91     Citation Subset:  IM    
Affiliation:
Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, Florida 32611, USA. adekloet@ufl.edu
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue, Brown / drug effects*,  metabolism
Adipose Tissue, White / drug effects*,  metabolism
Angiotensin II / administration & dosage*,  pharmacology*
Animals
Body Weight / drug effects
Brain / drug effects*
Dose-Response Relationship, Drug
Down-Regulation / drug effects
Drug Evaluation, Preclinical
Eating / drug effects
Infusion Pumps, Implantable
Infusions, Intraventricular
Infusions, Subcutaneous
Male
Metabolism / drug effects
Rats
Rats, Long-Evans
Grant Support
ID/Acronym/Agency:
DK-017844/DK/NIDDK NIH HHS; DK-056863/DK/NIDDK NIH HHS; DK-078201/DK/NIDDK NIH HHS; DK-087816/DK/NIDDK NIH HHS; DK-54890/DK/NIDDK NIH HHS; HL-096830/HL/NHLBI NIH HHS; NS-681222/NS/NINDS NIH HHS; R00 HL096830/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
11128-99-7/Angiotensin II
Comments/Corrections

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