Document Detail

Central angiotensin AT1 and muscarinic receptors in ITF expression on intracerebroventricular NaCl.
MedLine Citation:
PMID:  9688984     Owner:  NLM     Status:  MEDLINE    
In the present study, we investigated the expression pattern of the inducible transcription factors (ITF) c-Fos, c-Jun, JunB, JunD, and Krox-24 following intracerebroventricular injections of hyperosmolar saline (0.2, 0.3, and 0.6 M NaCl) and its mediation via angiotensin and/or muscarinic receptors. c-Fos, c-Jun, and Krox-24 were differentially expressed in organum vasculosum laminae terminalis, median preoptic area, subfornical organ (SFO), and paraventricular and supraoptic nuclei. Expression of c-Fos and c-Jun was inhibited by pretreatment with the angiotensin AT1 receptor antagonist losartan (10 and 20 nmol icv) following 0.20 and 0.30 M saline. Pretreatment with atropine (15 nmol icv) inhibited the 0.30 and 0.60 M NaCl-induced expression of c-Fos, c-Jun, and Krox-24 in all areas except the SFO. Coexpression of the ITF with vasopressin and oxytocin, the major effector peptides in osmoregulation, was demonstrated, implying the corresponding genes as putative target genes of the ITF. The results show a highly differentiated ITF expression pattern in the brain mediated by angiotensinergic and muscarinergic pathways, suggesting a finely tuned regulation of target genes.
E Moellenhoff; C J Lebrun; A Blume; J Culman; T Herdegen; T Unger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  275     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-08-27     Completed Date:  1998-08-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R234-44     Citation Subset:  IM    
Institute of Pharmacology, University of Kiel, 24105 Kiel; and German Institute for High Blood Pressure Research, 69120 Heidelberg, Germany.
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MeSH Terms
Atropine / pharmacology
Cerebral Ventricles / physiology*
DNA-Binding Proteins / biosynthesis*
Early Growth Response Protein 1
Gene Expression Regulation / drug effects
Hypothalamus / drug effects,  metabolism*
Immediate-Early Proteins*
Injections, Intraventricular
Losartan / administration & dosage,  pharmacology
Neurons / drug effects,  metabolism
Organ Specificity
Oxytocin / biosynthesis
Paraventricular Hypothalamic Nucleus / metabolism
Preoptic Area / metabolism
Proto-Oncogene Proteins c-fos / biosynthesis*
Proto-Oncogene Proteins c-jun / biosynthesis*
Rats, Wistar
Receptors, Angiotensin / physiology*
Receptors, Muscarinic / physiology*
Saline Solution, Hypertonic / administration & dosage,  pharmacology*
Supraoptic Nucleus / metabolism
Transcription Factors / biosynthesis*
Vasopressins / biosynthesis
Zinc Fingers
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Early Growth Response Protein 1; 0/Egr1 protein, rat; 0/Immediate-Early Proteins; 0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-jun; 0/Receptors, Angiotensin; 0/Receptors, Muscarinic; 0/Saline Solution, Hypertonic; 0/Transcription Factors; 11000-17-2/Vasopressins; 114798-26-4/Losartan; 50-56-6/Oxytocin; 51-55-8/Atropine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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