Document Detail

Central alpha-adrenoceptor influence over the cardiovascular reflexes activated by veratrine.
MedLine Citation:
PMID:  2548959     Owner:  NLM     Status:  MEDLINE    
Intravenous veratrine induced alterations in cardiovascular parameters in cats were used as a tool for assessing the influence of central alpha-adrenoceptors over reflex adjustments in the heart rate and blood pressure. Blockade of central alpha 2-adrenoceptors with idazoxan or yohimbine, inhibited, while their activation by clonidine, as also blockade of alpha 1-adrenoceptors, with prazosin, potentiated the veratrine induced bradycardia. The hypotensive effect was relatively unaltered by these treatments. Low doses of clonidine potentiated the veratrine-induced bradycardia. It appears that alpha 2-adrenoceptor mechanisms exert greater control over the reflex regulation of heart rate than over reflex control of blood pressure.
S Gurtu; K K Pant; J N Sinha
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Indian journal of medical research     Volume:  90     ISSN:  0971-5916     ISO Abbreviation:  Indian J. Med. Res.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-09-27     Completed Date:  1989-09-27     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  0374701     Medline TA:  Indian J Med Res     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  209-14     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects*
Heart Rate / drug effects*
Receptors, Adrenergic, alpha / physiology*
Veratrine / pharmacology*
Reg. No./Substance:
0/Receptors, Adrenergic, alpha; 62-59-9/Veratrine

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