| Central alpha-adrenergic control of blood pressure. Effects of clonidine withdrawal. | |
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MedLine Citation:
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PMID: 6295708 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies were undertaken to investigate the role of the CNS in withdrawal hypertension caused by abrupt cessation of long-term clonidine treatment. The studies were conducted on male wistar rats receiving clonidine, 100 micrograms/kg subcutaneously twice daily for seven days. Withdrawal hypertension occurred 16 to 18 hours following the last injection of clonidine. Pressor responses to posterior hypothalamic stimulation were significantly potentiated in the rats undergoing clonidine withdrawal, and the depressor response to a single injection of 10 micrograms of clonidine into the lateral cerebral ventricle was significantly attenuated in these animals. Studies on pithed rats demonstrated that destruction of the CNS eliminated the withdrawal hypertension. These data suggest that alpha-adrenoreceptors in the nucleus tractus solitarius play an important role in the normal maintenance of blood pressure, and a decrease in sensitivity of these receptors could result in the development of a hypertensive state. |
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Authors:
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S J Augustine; S Tachikawa; M F Lokhandwala; J P Buckley |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chest Volume: 83 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 1983 Feb |
Date Detail:
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Created Date: 1983-03-24 Completed Date: 1983-03-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 328-31 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Clonidine / adverse effects* Electric Stimulation Heart Rate / drug effects Humans Hypertension / chemically induced* Hypothalamus, Posterior / physiology Male Medulla Oblongata / physiology* Rats Rats, Inbred Strains Receptors, Adrenergic / physiology* Receptors, Adrenergic, alpha / physiology* Substance Withdrawal Syndrome / physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Adrenergic; 0/Receptors, Adrenergic, alpha; 4205-90-7/Clonidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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