Document Detail


Central alpha 2-adrenoceptors and blood pressure regulation in the rat.
MedLine Citation:
PMID:  7672004     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of alpha 2-adrenoceptors in the central regulation of blood pressure has been questioned, since drugs such as clonidine stimulate both alpha 2-adrenoceptors and imidazoline-preferring receptors. The present work was undertaken to study the influence of alpha 2D-adrenoceptors, encoded by the RG20 gene, on blood pressure in the rat. An antisense phosphodiester oligodeoxynucleotide, directed at nucleotides 4-21 of the RG20 gene, was injected in the right lateral cerebral ventricle, causing an increase in systolic blood pressure, both at 1 and 2 days after the injection, when compared to groups of control rats (injected with the sense oligodeoxynucleotide or a missense oligodeoxynucleotide or distilled water). Antisense oligodeoxynucleotides directed either at nucleotides 65-82 of the RG10 gene (encoding for alpha 2C-adrenoceptors) or at nucleotides 26-43 of the RNG gene (encoding for alpha 2B-adrenoceptors), failed to produce any change in blood pressure after being injected. We conclude that the alpha 2-adrenoceptor encoded by the RG20 gene may play a role in blood pressure regulation in the rat.
Authors:
J P Nunes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  278     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-10-18     Completed Date:  1995-10-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  183-5     Citation Subset:  IM    
Affiliation:
Instituto de Farmacologia e Terapêutica, Faculdade de Medicina, Porto, Portugal.
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MeSH Terms
Descriptor/Qualifier:
Animals
Base Sequence
Blood Pressure / drug effects,  physiology*
Injections, Intraventricular
Male
Molecular Sequence Data
Oligonucleotides, Antisense / administration & dosage,  pharmacology
Rats
Rats, Wistar
Receptors, Adrenergic, alpha-2 / genetics,  physiology*
Chemical
Reg. No./Substance:
0/Oligonucleotides, Antisense; 0/Receptors, Adrenergic, alpha-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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