Document Detail

Central administration of nicotine suppresses tracheobronchial cough in anesthetized cats.
MedLine Citation:
PMID:  25477349     Owner:  NLM     Status:  Publisher    
Background and purpose. We tested the hypothesis that nicotine (NIC), which acts peripherally to promote coughing, might inhibit reflex cough at a central site. Experimental approach. NIC was administered via the vertebral artery (ia) to the brainstem circulation and by microinjections into a restricted area of the caudal ventral respiratory column in 33 pentobarbital anesthetized spontaneously breathing cats. The number of coughs induced by mechanical stimulation of the tracheobronchial airways, amplitudes of the diaphragm, abdominal muscle, and laryngeal muscles EMGs, and several temporal characteristics of cough were analyzed after administration of NIC and compared to those during control and recovery period. Key results. (-) NIC (ia) reduced cough number, cough expiratory efforts, blood pressure, and heart rate in a dose-dependent manner. (-) NIC did not alter temporal characteristics of the cough motor pattern. Pretreatment with mecamylamine prevented the effect of (-) NIC on blood pressure and heart rate, but did not block the antitussive action of this drug. (+) NIC was less potent than (-) NIC for inhibition of cough. Microinjections of (-) NIC into the caudal ventral respiratory column produced similar inhibitory effects on cough as administration of this isomer by the ia route. Mecamylamine microinjected in the region just before nicotine did not significantly reduce the cough suppressant effect of nicotine. Conclusions and Implications. Nicotinic acetylcholine receptors significantly modulate functions of brainstem and in particular caudal ventral respiratory column neurons involved in expression of the tracheobronchial cough reflex by a mecamylamine insensitive mechanism.
Ivan Poliacek; Melanie J Rose; Teresa E Pitts; Ashley Mortensen; Lu Wen-Chi Corrie; Paul W Davenport; Donald C Bolser
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-12-4
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  -     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-12-5     Completed Date:  -     Revised Date:  2014-12-6    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  jap.00075.2014     Citation Subset:  -    
Copyright Information:
Copyright © 2014, Journal of Applied Physiology.
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