Document Detail

Central administration of neuromedin U suppresses food intake in chicks.
MedLine Citation:
PMID:  17445984     Owner:  NLM     Status:  MEDLINE    
The appetite-suppressive action of brain-gut peptides is similar in both chickens and mammals. In mammals, the brain-gut peptide neuromedin U (NMU) suppresses food intake via hypothalamic neuropeptides, corticotropin-releasing factor (CRF), oxytocin, and arginine-vasopressin. In chickens, central administration of CRF, oxytocin, or arginine-vasotocin (AVT, a nonmammalian equivalent of arginine-vasopressin) suppresses food intake. However, the anorexigenic action of NMU in chickens has not yet been identified. In the present study, we analyzed the effects of the central administration of NMU on food intake and hypothalamic mRNA levels of CRF, AVT and mesotocin (a nonmammalian equivalent of oxytocin) in chicks. Intracerebroventricular administration of NMU in chicks significantly suppressed food intake and induced wing-flapping behavior. NMU also significantly upregulated mRNA expression of CRF and AVT, but did not influence mRNA expression of mesotocin in the hypothalamus. These results suggest that NMU functions as an appetite-suppressive peptide via CRF and AVT in the central nervous system in chicks.
Hiroshi Kamisoyama; Kazuhisa Honda; Takaoki Saneyasu; Kunio Sugahara; Shin Hasegawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-04-01
Journal Detail:
Title:  Neuroscience letters     Volume:  420     ISSN:  1872-7972     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-28     Completed Date:  2009-06-02     Revised Date:  2009-06-23    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM    
Department of Animal Science, Faculty of Agriculture, Kobe University, Kobe 657-8501, Japan.
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MeSH Terms
Arginine Vasopressin / biosynthesis,  pharmacology
Behavior, Animal / drug effects
Chickens / physiology*
Corticotropin-Releasing Hormone / biosynthesis,  pharmacology
Dose-Response Relationship, Drug
Eating / drug effects*
Injections, Intraventricular
Neuropeptides / administration & dosage,  pharmacology*
Oxytocin / analogs & derivatives,  biosynthesis,  pharmacology
RNA, Messenger / biosynthesis,  genetics
Reg. No./Substance:
0/Neuropeptides; 0/RNA, Messenger; 113-79-1/Arginine Vasopressin; 117505-80-3/neuromedin U; 362-39-0/mesotocin; 50-56-6/Oxytocin; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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