Document Detail

Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats.
MedLine Citation:
PMID:  17321524     Owner:  NLM     Status:  MEDLINE    
In this study, we examined the effects of intracerebroventricular administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity in diet-induced obese (DIO) rats. Although MTII treatment significantly decreased food intake and body weight for 10 days, there was no significant difference in body weight between MTII and pair-fed groups. The insulin tolerance test showed that insulin sensitivity was significantly improved in the MTII group compared to the pair-fed group. Furthermore, MTII treatment increased the number of small-sized adipocytes in epididymal white adipose tissues, suggesting that MTII increased insulin sensitivity through action on the white adipose tissues in DIO rats.
Ryoichi Banno; Hiroshi Arima; Masayuki Hayashi; Motomitsu Goto; Minemori Watanabe; Ikuko Sato; Nobuaki Ozaki; Hiroshi Nagasaki; Noriyuki Ozaki; Yutaka Oiso
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Publication Detail:
Type:  Journal Article     Date:  2007-02-16
Journal Detail:
Title:  FEBS letters     Volume:  581     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-16     Completed Date:  2007-05-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1131-6     Citation Subset:  IM    
Department of Endocrinology and Diabetes, Field of Internal Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
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MeSH Terms
Adipocytes / cytology,  drug effects
Adipose Tissue, White / cytology,  drug effects
Body Weight / drug effects
Cytokines / blood
Eating / drug effects
Insulin / pharmacology*
Insulin Resistance
Melanocortins / agonists*
Peptides, Cyclic / administration & dosage*
Rats, Sprague-Dawley
alpha-MSH / administration & dosage,  analogs & derivatives*
Reg. No./Substance:
0/Cytokines; 0/Melanocortins; 0/Peptides, Cyclic; 11061-68-0/Insulin; 121062-08-6/melanotan-II; 581-05-5/alpha-MSH

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