Document Detail

Central administration of glucagon suppresses food intake in chicks.
MedLine Citation:
PMID:  17324515     Owner:  NLM     Status:  MEDLINE    
Food intake in chickens is regulated in a manner similar to that in mammals. Corticotropin-releasing factor (CRF), which increases the plasma corticosterone concentration, plays an important role as a mediator of many appetite-suppressive peptides in the central nervous system in both species. Central administration of glucagon suppresses food intake in rats. However, the anorexigenic action of glucagon in chicks has not yet been identified. In the present study, we investigated the effects of central administration of glucagon on food intake in chicks. Intracerebroventricular administration of glucagon in chicks significantly suppressed food intake and significantly induced hyperglycemia. In contrast, peripheral administration of the same dose of glucagon did not influence food intake and plasma glucose concentration. These results suggest that glucagon functions in chicks as an appetite-suppressive peptide in the central nervous system. Intracerebroventricular administration of glucagon in chicks also significantly increased CRF mRNA expression and plasma corticosterone concentration, suggesting that CRF acts as a downstream molecule for a glucagon-induced appetite-suppressive pathway in chicks. It is likely that the induction of hyperglycemia by central administration of glucagon is involved in its anorexigenic action, because peripheral administration of glucose in chicks suppressed food intake. These results suggest that CRF- and/or hyperglycemia-mediated pathways are involved in the anorexigenic action of glucagon in chicks.
Kazuhisa Honda; Hiroshi Kamisoyama; Noboru Saito; Yohei Kurose; Kunio Sugahara; Shin Hasegawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-02-07
Journal Detail:
Title:  Neuroscience letters     Volume:  416     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-26     Completed Date:  2007-06-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  198-201     Citation Subset:  IM    
Department of Animal Science, Faculty of Agriculture, Kobe University, Kobe 657-8501, Japan.
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MeSH Terms
Appetite Regulation / physiology*
Blood Glucose
Corticosterone / blood
Corticotropin-Releasing Hormone / metabolism
Eating / physiology*
Glucagon / administration & dosage,  metabolism*
Hypothalamus / physiology*
Injections, Intraventricular
RNA, Messenger / analysis
Reverse Transcriptase Polymerase Chain Reaction
Reg. No./Substance:
0/Blood Glucose; 0/RNA, Messenger; 50-22-6/Corticosterone; 9007-92-5/Glucagon; 9015-71-8/Corticotropin-Releasing Hormone

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