Document Detail


Central actions of R15, a putative peptidergic neuron in Aplysia.
MedLine Citation:
PMID:  3572386     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report that the bursting pacemaker neuron R15 has central actions on other identified neurons in the abdominal ganglion of Aplysia california. The follower cells are located on the dorsal surface of the left lower quadrant of the ganglion and include members of the LC cell cluster. A spontaneous burst of impulses in R15 produces a slow, graded, excitatory potential of up to 8 mV in follower cells. The response begins about 2-3 s after the first impulse in an R15 burst, and reaches its peak at about 4-6 s (corresponding approximately to the end of the R15 burst). In some preparations a biphasic response was seen composed of the early depolarization followed by a slower excitatory or inhibitory phase. All the responses were blocked when R15 was hyperpolarized to prevent spiking. The magnitude of the response was reduced in a graded fashion by prematurely terminating the R15 burst with hyperpolarizing current and was increased when depolarizing current was injected into R15 during a burst. Central actions of R15 were observed in only 28% of our preparations, and their presence may depend on unknown physiological factors. The effects are likely to be mediated by R15 neuropeptides. The accessibility of both R15 and its targets in this preparation should facilitate further analysis of this interaction.
Authors:
R O Brown; E Mayeri
Related Documents :
21520006 - Probability of urinary tract infection in infants with ureteropelvic junction obstructi...
21135346 - Hour-specific bilirubin nomogram in infants with abo incompatibility and direct coombs-...
21399966 - Posthemorrhagic hydrocephalus in very low birth weight infants-a new gentle surgical te...
3572386 - Central actions of r15, a putative peptidergic neuron in aplysia.
23188956 - Refractory cardiogenic shock in an infant with congenital hypothyroidism.
16961196 - Motor vehicle deaths: failed policy analysis and neglected policy.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurobiology     Volume:  18     ISSN:  0022-3034     ISO Abbreviation:  J. Neurobiol.     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-06-11     Completed Date:  1987-06-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0213640     Medline TA:  J Neurobiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3-13     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abdomen / innervation
Animals
Aplysia / physiology*
Central Nervous System / physiology*
Electric Stimulation
Ganglia / cytology,  physiology
Neurons / physiology*
Peptides / physiology*
Synapses / physiology
Grant Support
ID/Acronym/Agency:
NS 16490/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Peptides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Development of rat soleus endplate membrane following denervation at birth.
Next Document:  Silencing normal input permits regenerating foreign afferents to innervate an identified crayfish se...