| Central pontine and extrapontine myelinolysis that developed during alcohol withdrawal, without hyponatremia, in a chronic alcoholic. | |
| | |
MedLine Citation:
|
PMID: 20228603 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Central pontine myelinolysis (CPM) and extrapontine myelinolysis (EPM) are osmotic demyelination syndrome. A 45-year-old man with a history of alcoholism visited the ER with dysarthria and dysphagia for 2 days. These symptoms occurred 3 days after he had stopped drinking alcohol. The neurological symptoms progressed to anarthria, pseudobulbar palsy and gait disturbance. During admission, the electrolyte studies were within the normal range. Diffusion-weighted images revealed high signal intensities in the pons, thalamus and basal ganglia. Apparent diffusion coefficient image showed low signal intensities in the pontine lesion, but isosignal intensities in the extrapontine lesion. The symptoms gradually improved after 1 month with only conservative treatment. The 1 month-follow-up MRI showed significant reduction of the previous extrapontine lesions. These findings suggest that cytotoxic edema is central to the pathogenesis of CPM, but vasogenic edema plays an important role in the pathogenesis of EPM occurring during alcohol withdrawal. |
| | |
Authors:
|
Jae Young An; Sung Kyung Park; Si Ryung Han; In Uk Song |
Related Documents
:
|
16489173 - Hypoplasia and neuronal immaturity of the hypoglossal nucleus in sudden infant death. 18591853 - Legionnaires' disease with hypoperfusion in the cerebellum and frontal lobe on single p... 17634653 - Polarized ir microscopic imaging of articular cartilage. |
Publication Detail:
|
Type: Case Reports; Journal Article Date: 2010-03-15 |
Journal Detail:
|
Title: Internal medicine (Tokyo, Japan) Volume: 49 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-03-15 Completed Date: 2010-06-10 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
|
Languages: eng Pagination: 615-8 Citation Subset: IM |
Affiliation:
|
Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea. nrjyan@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alcoholism
/
complications*,
therapy Edema / complications Ethanol / adverse effects* Humans Male Middle Aged Myelinolysis, Central Pontine / diagnosis, etiology* Prognosis Substance Withdrawal Syndrome / complications* |
| Chemical | |
Reg. No./Substance:
|
64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Myasthenia gravis accompanied by premature ovarian failure and aggravation by estrogen.
Next Document: Coexistence of familial mediterranean Fever and juvenile idiopathic arthritis with osteoporosis succ...