Document Detail

Central and Peripheral Fatigue: Interaction during Cycling Exercise in Humans.
MedLine Citation:
PMID:  21502884     Owner:  NLM     Status:  Publisher    
Existing evidence suggests that exercise-induced alterations of the metabolic milieu of locomotor muscle, and associated peripheral muscle fatigue, affects the central projection of thin fiber muscle afferents. These neurons provide inhibitory feedback to the central nervous system (CNS) and thereby influence the magnitude of central motor drive (CMD) during high intensity whole body endurance exercise. The purpose of this proposed feedback-loop would be to regulate and restrict the development of exercise-induced peripheral muscle fatigue, and / or associated sensory feedback, to an "individual critical threshold". This centrally mediated restriction in the development of peripheral locomotor muscle fatigue might thereby help to prevent excessive disturbance of muscle homeostasis and potential harm to the organism. It appears that the regulatory mechanism is dominant during exercise under "normal" conditions, but might become secondary in the face of extreme environmental influences such as severe hypoxia or heat. Most recent data is used to emphasize how the proposed feedback-loop might be a key factor limiting performance during high-intensity whole body endurance exercise.
Markus Amann
Related Documents :
8157384 - The cardiocirculatory reaction to isokinetic exercises in dependence on the form of exe...
17373594 - Acute effects of stretching on muscle stiffness after a bout of exhaustive eccentric ex...
16306504 - An exercise programme for the management of lateral elbow tendinopathy.
16015144 - Biochemical and hormonal responses during an intercollegiate football season.
11677004 - The value of muscle exercise in patients with amyotrophic lateral sclerosis.
1678224 - Local cholinergic sweat stimulation in atopic dermatitis. an evaporimetric study.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-14
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Medicine, University of Utah.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Startup circuit training program reduces metabolic risk in Latino adolescents.
Next Document:  Absolute and Relative Energy Costs Of Walking In A Brazilian Adult Probability Sample.