Document Detail


Central and Peripheral Fatigue: Interaction during Cycling Exercise in Humans.
MedLine Citation:
PMID:  21502884     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Existing evidence suggests that exercise-induced alterations of the metabolic milieu of locomotor muscle, and associated peripheral muscle fatigue, affects the central projection of thin fiber muscle afferents. These neurons provide inhibitory feedback to the central nervous system (CNS) and thereby influence the magnitude of central motor drive (CMD) during high intensity whole body endurance exercise. The purpose of this proposed feedback-loop would be to regulate and restrict the development of exercise-induced peripheral muscle fatigue, and / or associated sensory feedback, to an "individual critical threshold". This centrally mediated restriction in the development of peripheral locomotor muscle fatigue might thereby help to prevent excessive disturbance of muscle homeostasis and potential harm to the organism. It appears that the regulatory mechanism is dominant during exercise under "normal" conditions, but might become secondary in the face of extreme environmental influences such as severe hypoxia or heat. Most recent data is used to emphasize how the proposed feedback-loop might be a key factor limiting performance during high-intensity whole body endurance exercise.
Authors:
Markus Amann
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-14
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Medicine, University of Utah.
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