Document Detail

Central L-arginine reduced stress responses are mediated by L-ornithine in neonatal chicks.
MedLine Citation:
PMID:  18219550     Owner:  NLM     Status:  MEDLINE    
Recently, we observed that central administration of L-arginine attenuated stress responses in neonatal chicks, but the contribution of nitric oxide (NO) to this response was minimal. The sedative and hypnotic effects of L-arginine may be due to L-arginine itself and/or its metabolites, excluding NO. To clarify the mechanism, the effect of intracerebroventricular (i.c.v.) injection of L-arginine metabolites on behavior under social separation stress was investigated. The i.c.v. injection of agmatine, a guanidino metabolite of L-arginine, had no effect during a 10 min behavioral test. In contrast, the i.c.v. injection of L-ornithine clearly attenuated the stress response in a dose-dependent manner, and induced sleep-like behavior. The L-ornithine concentration in the telencephalon and diencephalon increased following the i.c.v. injection of L-arginine. In addition, several free amino acids including L-alanine, glycine, L-proline and L-glutamic acid concentrations increased in the telencephalon. In conclusion, it appears that L-ornithine, produced by arginase from L-arginine in the brain, plays an important role in the sedative and hypnotic effects of L-arginine observed during a stress response. In addition, several other amino acids having a sedative effect might partly participate in the sedative and hypnotic effects of L-arginine.
R Suenaga; H Yamane; S Tomonaga; M Asechi; N Adachi; Y Tsuneyoshi; I Kurauchi; H Sato; D M Denbow; M Furuse
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-25
Journal Detail:
Title:  Amino acids     Volume:  35     ISSN:  1438-2199     ISO Abbreviation:  Amino Acids     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-05     Completed Date:  2008-08-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  107-13     Citation Subset:  IM    
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Amino Acids
Animals, Newborn
Arginine / metabolism,  pharmacology*
Behavior, Animal / drug effects*
Brain Chemistry / drug effects*
Diencephalon / metabolism
Dose-Response Relationship, Drug
Hypnotics and Sedatives / metabolism,  pharmacology*
Ornithine / metabolism*
Stress, Physiological / metabolism*
Telencephalon / metabolism
Reg. No./Substance:
0/Amino Acids; 0/Hypnotics and Sedatives; 7006-33-9/Ornithine; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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