| Central L-arginine reduced stress responses are mediated by L-ornithine in neonatal chicks. | |
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MedLine Citation:
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PMID: 18219550 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recently, we observed that central administration of L-arginine attenuated stress responses in neonatal chicks, but the contribution of nitric oxide (NO) to this response was minimal. The sedative and hypnotic effects of L-arginine may be due to L-arginine itself and/or its metabolites, excluding NO. To clarify the mechanism, the effect of intracerebroventricular (i.c.v.) injection of L-arginine metabolites on behavior under social separation stress was investigated. The i.c.v. injection of agmatine, a guanidino metabolite of L-arginine, had no effect during a 10 min behavioral test. In contrast, the i.c.v. injection of L-ornithine clearly attenuated the stress response in a dose-dependent manner, and induced sleep-like behavior. The L-ornithine concentration in the telencephalon and diencephalon increased following the i.c.v. injection of L-arginine. In addition, several free amino acids including L-alanine, glycine, L-proline and L-glutamic acid concentrations increased in the telencephalon. In conclusion, it appears that L-ornithine, produced by arginase from L-arginine in the brain, plays an important role in the sedative and hypnotic effects of L-arginine observed during a stress response. In addition, several other amino acids having a sedative effect might partly participate in the sedative and hypnotic effects of L-arginine. |
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Authors:
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R Suenaga; H Yamane; S Tomonaga; M Asechi; N Adachi; Y Tsuneyoshi; I Kurauchi; H Sato; D M Denbow; M Furuse |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-01-25 |
Journal Detail:
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Title: Amino acids Volume: 35 ISSN: 1438-2199 ISO Abbreviation: Amino Acids Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-05 Completed Date: 2008-08-19 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9200312 Medline TA: Amino Acids Country: Austria |
Other Details:
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Languages: eng Pagination: 107-13 Citation Subset: IM |
Affiliation:
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Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids Animals Animals, Newborn Arginine / metabolism, pharmacology* Behavior, Animal / drug effects* Brain Chemistry / drug effects* Chickens Diencephalon / metabolism Dose-Response Relationship, Drug Hypnotics and Sedatives / metabolism, pharmacology* Ornithine / metabolism* Stress, Physiological / metabolism* Telencephalon / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Hypnotics and Sedatives; 7006-33-9/Ornithine; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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