Document Detail


Central hemodynamics in prehypertension: effect of the β-adrenergic antagonist nebivolol.
MedLine Citation:
PMID:  23282127     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the current study was to characterize the effects of the novel β-adrenergic antagonist nebivolol on central aortic blood pressures, arterial properties, and nitroxidergic activity in individuals with prehypertension. Prehypertension is emerging as a major risk factor for several adverse cardiovascular consequences. Increased pulse wave velocity, aortic augmentation index, and aortic blood pressures have been linked with augmented risk of cardiovascular disease and mortality. While the effects of antihypertensive drugs on these parameters in hypertensive patients have been studied, there are limited data so far in prehypertension. Fifty individuals with prehypertension were randomized to either nebivolol (5 mg per day) or placebo in a double-blind clinical trial. Patients underwent measurement of pulse wave velocity as well as aortic blood pressure and aortic augmentation index via pulse wave analysis at baseline and 8 weeks. Patients also had blood and urine biochemistries done at each visit. Nebivolol achieved significant reductions in central aortic systolic (P=.011), diastolic (P=.009), and mean arterial blood pressure (P=.002). Pulse wave velocity trended toward improvement but did not achieve significance (P=.088). Nitric oxide production, measured as urinary nitrite/nitrite excretion, also rose substantially in the nebivolol group (by approximately 60%, P=.030). Central blood pressures can be effectively lowered by β-blockade while patients are still in the prehypertension phase, and the effects may be coupled to improve nitric oxide release by the drug.
Authors:
Jason T Davis; Dalal N Pasha; Srikrishna Khandrika; Maple M Fung; Milos Milic; Daniel T O'Connor
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-10-26
Journal Detail:
Title:  Journal of clinical hypertension (Greenwich, Conn.)     Volume:  15     ISSN:  1751-7176     ISO Abbreviation:  J Clin Hypertens (Greenwich)     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-03     Completed Date:  2013-06-14     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  100888554     Medline TA:  J Clin Hypertens (Greenwich)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  69-74     Citation Subset:  IM    
Copyright Information:
© 2012 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adrenergic beta-1 Receptor Antagonists / therapeutic use*
Adult
Benzopyrans / therapeutic use*
Blood Pressure / drug effects*
Chi-Square Distribution
Double-Blind Method
Enzyme-Linked Immunosorbent Assay
Ethanolamines / therapeutic use*
Female
Hemodynamics / drug effects*
Humans
Hypertension / drug therapy*
Male
Middle Aged
Placebos
Statistics, Nonparametric
Treatment Outcome
Grant Support
ID/Acronym/Agency:
5P60MD000220/MD/NIMHD NIH HHS; 5UL1RR031980/RR/NCRR NIH HHS; HL58120/HL/NHLBI NIH HHS; KL2 TR000099/TR/NCATS NIH HHS; P01 HL058120/HL/NHLBI NIH HHS; P60 MD000220/MD/NIMHD NIH HHS; R01 DK094894/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Adrenergic beta-1 Receptor Antagonists; 0/Benzopyrans; 0/Ethanolamines; 0/Placebos; 030Y90569U/nebivolol
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