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Centenary of the Anglo-American High Altitude Expedition to Pikes Peak. 2011 Paton Lecture.
MedLine Citation:
PMID:  21948193     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract2011 marks the 100th anniversary of one of the most important early research expeditions to high altitude. The principal participants were J.S. Haldane and C.G. Douglas from Oxford, Y. Henderson from Yale, and E.C. Schneider from Colorado College. Pikes Peak just outside Colorado Springs proved to be an excellent venue because of its substantial altitude of 4300 m, convenient access via a cog railway, and comfortable living accommodation. The expedition had a classical design with measurements made first at sea level, then on the summit for five weeks, and then at sea level again. The extensive scientific program included descriptions of acute mountain sickness, many measurements of partial pressures in alveolar gas and arterial blood, changes in ventilation including periodic breathing, exercise measurements, and a large number of blood studies. One error was the conclusion that the arterial PO2 could considerably exceed the alveolar value implying oxygen secretion by the lung, but this should not detract from the other important advances. Mabel FitzGerald was invited to be a member of the expedition but did not join the men on the summit. Instead she visited various mining camps in Colorado at somewhat lower altitudes and carried out classical studies of alveolar gas partial pressures and hemoglobin values. Indeed her results of alveolar PO2 and PCO2 are frequently cited today. The Pikes Peak expedition was a model and it had an extensive influence on later studies.
Authors:
John B West
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-23
Journal Detail:
Title:  Experimental physiology     Volume:  -     ISSN:  1469-445X     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
University of California, San Diego.
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