| Cement from nanocrystalline hydroxyapatite: effect of calcium phosphate ratio. | |
| | |
MedLine Citation:
|
PMID: 16362220 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Nanocrystalline hydroxyapatite (nHA) can be mixed with phosphoric acid to form a brushite cement; a degradable inorganic bone filling material. nHA was precipitated from reactants of calcium to phosphate (Ca/P) ratio 0.8 to 2.0 and mixed with phosphoric acid, which resulted in the formation of a brushite cement. Cement was also formed by mixing microcrystalline calcium phosphates, beta-tricalcium phosphate, hydroxyapatite and tetracalcium phosphate with phosphoric acid solution. Cement produced with nHA was stronger in compression than that formed with crystalline calcium phosphate phases. Setting time, strength and composition of cement produced with nHA was dependant on both the Ca/P ratio of nHA and the concentration of phosphoric acid in cement slurry. Increasing phosphoric acid concentration increased compressive strength whilst reducing the initial setting time of cement. Reducing the Ca/P ratio of nHA precipitation reactants retarded the setting and increased the extent of reaction of cements. This finding was unexpected and suggests that Ca/P ratio may strongly affect dissolution behaviour and this parameter is more important than stoichiometry in determining extent of reaction in this system. This study demonstrated that the wide variation in stoichiometry that may be attained in nanocrystalline apatite may be utilised to change cement performance and setting behaviour. |
| | |
Authors:
|
K J Lilley; U Gbureck; A J Wright; D F Farrar; J E Barralet |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of materials science. Materials in medicine Volume: 16 ISSN: 0957-4530 ISO Abbreviation: - Publication Date: 2005 Dec |
Date Detail:
|
Created Date: 2005-12-19 Completed Date: 2006-05-26 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9013087 Medline TA: J Mater Sci Mater Med Country: United States |
Other Details:
|
Languages: eng Pagination: 1185-90 Citation Subset: IM |
Affiliation:
|
Biomaterials Unit, School of Dentistry, University of Birmingham, B4 6NN, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Bone Cements* Calcium Phosphates / chemistry* Durapatite* Nanotechnology X-Ray Diffraction |
| Chemical | |
Reg. No./Substance:
|
0/Bone Cements; 0/Calcium Phosphates; 10103-46-5/calcium phosphate; 1306-06-5/Durapatite |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of TiO2, ZrO2 and Al2O3 dopants on the compressive strength of tricalcium phosphate.
Next Document: An experimental and theoretical composite model of the human mandible.