Document Detail

Celsior preserved cardiac mechanoenergetics better than popular solutions in canine hearts.
MedLine Citation:
PMID:  16427870     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Better protective effects of Celsior on cardiac function than the other conventional solutions have been reported in acute experiments and in clinical trials for at-risk patients. However, no study has yet precisely elucidated how these preservation solutions affect cardiac mechanoenergetics. Therefore, we evaluated the effects of St. Thomas' Hospital solution No. 2, University of Wisconsin solution, and Celsior on left ventricular contractility (Emax: end-systolic pressure-volume ratio) and oxygen consumption. METHODS: We used 32 canine excised cross-circulated hearts. Twenty-three hearts served as donor hearts after hypothermic ischemia with one of the three solutions, and the remaining 9 served as controls. After arrest with each solution, the hearts were preserved for 4 hours at 4 degrees C. Then, we measured left ventricular pressure, volume, and oxygen consumption to obtain Emax and the relation between ventricular pressure-volume area (a measure of total mechanical energy) and oxygen consumption. We also evaluated the oxygen cost of Emax by changing Emax with calcium administration. RESULTS: Celsior did not significantly affect E(max) (6.3 +/- 2.4 in control versus 5.3 +/- 1.3 mm Hg.mL(-1).100 g with Celsior) nor the oxygen cost of Emax (1.2 +/- 0.6 versus 1.6 +/- 0.5 mL Hg(-1).beat(-1).100 g(-2), respectively). In contrast, St. Thomas' Hospital and University of Wisconsin solutions significantly decreased Emax (4.5 +/- 1.1 and 3.5 +/- 0.9 mm Hg.mL(-1).100 g, respectively) and increased the oxygen cost of Emax (2.5 +/- 0.8 and 2.4 +/- 0.9 mL Hg(-1).beat(-1).100 g(-2), respectively) compared with control and Celsior-preserved hearts. The slope and intercept of the oxygen consumption versus pressure-volume area relation showed no significant difference among the four groups. CONCLUSIONS: Celsior showed better protective effects on cardiac mechanoenergetics than St. Thomas' Hospital and University of Wisconsin solutions in the acute phase of heart transplantation.
Yu Oshima; Satoshi Mohri; Juichiro Shimizu; Gentaro Iribe; Takeshi Imaoka; Waso Fujinaka; Takahiko Kiyooka; Kozo Ishino; Shunji Sano; Fumihiko Kajiya; Hiroyuki Suga
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  81     ISSN:  1552-6259     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-23     Completed Date:  2006-08-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  658-64     Citation Subset:  AIM; IM    
Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Disaccharides / pharmacology
Electrolytes / pharmacology
Energy Metabolism
Glutamates / pharmacology
Glutathione / pharmacology
Heart / physiology*
Heart Transplantation / methods*
Histidine / pharmacology
Mannitol / pharmacology
Myocardial Contraction
Organ Preservation Solutions / pharmacology*
Oxygen Consumption
Reg. No./Substance:
0/Celsior; 0/Disaccharides; 0/Electrolytes; 0/Glutamates; 0/Organ Preservation Solutions; 69-65-8/Mannitol; 70-18-8/Glutathione; 71-00-1/Histidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Prevention of postoperative pericardial adhesions with a novel regenerative collagen sheet.
Next Document:  Physical activity patterns of children after neonatal arterial switch operation.