Document Detail


Cellulose-based haemodialysis membranes: biocompatibility and functional performance compared.
MedLine Citation:
PMID:  1317525     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Regenerated cellulose membranes are widely used in the treatment of renal failure. The presence of hydroxyl (OH) groups on the membrane surface plays an important role in initiating complement activation and also influences thrombogenicity. The OH groups may be masked or reduced by alteration of the manufacturing process of the membrane. We have undertaken a clinical study of four cellulose-based membranes (Cuprophan, Hemophan, cellulose acetate, and cellulose triacetate) in which the hydroxyl groups of the membrane have been replaced and the magnitude of replacement has varied from less than 1% to greater than 80%, to assess the role that these modifications play in functional performance, biocompatibility (neutropenia, leukocyte activation, anaphylatoxin generation, and hypoxaemia). Our findings indicate that there does not appear to be a straightforward correlation between the numbers of hydroxyl groups replaced and modification of biocompatibility, suggesting that not all hydroxyl groups behave in a similar way.
Authors:
C Woffindin; N A Hoenich; J N Matthews
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  7     ISSN:  0931-0509     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  1992  
Date Detail:
Created Date:  1992-06-29     Completed Date:  1992-06-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  340-5     Citation Subset:  IM    
Affiliation:
Department of Medicine, School of Clinical Medical Sciences, Newcastle upon Tyne, UK.
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MeSH Terms
Descriptor/Qualifier:
Cellulose* / chemistry
Complement Activation
Humans
Hydroxylation
Kidney, Artificial*
Leukocyte Count
Materials Testing
Membranes, Artificial*
Neutrophils / enzymology
Oxygen / blood
Pancreatic Elastase / blood
Chemical
Reg. No./Substance:
0/Membranes, Artificial; 7782-44-7/Oxygen; 9004-34-6/Cellulose; EC 3.4.21.36/Pancreatic Elastase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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