Document Detail


Cellularity of the alveolar walls in smokers and its relation to alveolar destruction. Functional implications.
MedLine Citation:
PMID:  2350097     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inflammatory cells are believed to play an important role in the pathogenesis of emphysema; however, a relationship between presence of cells in the lung parenchyma and its destruction has never been shown. The aim of this study was to quantitate alveolar septal cellularity in smokers' lungs and to investigate its relationship with parenchymal destruction and lung function. The lungs of 23 smokers (SS) undergoing thoracotomy for localized pulmonary lesions were compared with those of eight nonsmokers (NS) and five smokers (AS) who died suddenly of nonrespiratory causes. Pulmonary function tests were performed within 1 wk of surgery in SS. For each subject, we quantitated alveolar wall cells (CELLS), an index of alveolar wall destruction (DI), and the mean linear intercept (Lm). As no significant differences were found between S and AS with regard to these indices, we combined them (Group S) for comparison with NS. Although Lm was not significantly different between S and NS, (0.331 +/- 0.072 versus 0.288 +/- 0.038), CELLS and DI were higher in S than in NS (48 +/- 8 versus 25 +/- 2 cells/mm, p less than 0.001; 47 +/- 20 versus 17 +/- 5, p less than 0.001, respectively). Further, CELLS and DI were significantly correlated (r = 0.799, p less than 0.001). The number of polymorphonuclear cells (PMN) in S can exceed that in NS by as much as 5-fold; however, PMN were inversely correlated with parenchymal destruction (DI) (r = 0.598, p less than 0.01). Thus, smokers' lungs have alveolar septal hypercellularity, possibly inflammatory, and closely related to destruction involving cells other than the PMN.
Authors:
D Eidelman; M P Saetta; H Ghezzo; N S Wang; J R Hoidal; M King; M G Cosio
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  141     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-07-09     Completed Date:  1990-07-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1547-52     Citation Subset:  AIM; IM    
Affiliation:
Respiratory Division, Royal Victoria Hospital, Montreal, Quebec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Aged
Female
Humans
Male
Middle Aged
Neutrophils / pathology
Pulmonary Alveoli / pathology*
Pulmonary Emphysema / etiology*,  pathology
Respiratory Function Tests
Smoking / pathology*,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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