| Cellular and subcellular distribution of iron in the lamina propria of rat duodenum. | |
| | |
MedLine Citation:
|
PMID: 6467343 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cellular and subcellular distribution of iron in the lamina propria of rat duodenum was studied after a single i.p. injection of iron dextran, using electron microscopy and peroxidase cytochemistry. X-ray spectrum microanalysis was used for positive identification of iron. Iron-containing particles (IP) were found in the cytoplasm of three cell types, viz. macrophages, pericytic reticular cells and sheathing fibrocytes. IP-containing organelles in lamina propria cells were more heterogeneous compared to absorptive cells and, in addition, some differences were noted in the subcellular distribution of IP in the 3 cell types. A common denominator in these 3 cell types was the presence of endogenous peroxidase, also shared by Kupffer cells which are known to be involved in iron storage. Peroxidase activity was absent in absorptive epithelial cells. It is hypothesized that the cells of the lamina propria, like Kupffer cells, may be the site of storage of excess iron absorbed, releasing iron upon demand and migrating into the lumen to prevent iron overload. In this fashion they may regulate the exchange of iron with the environment. The presence of peroxidase in these as well as Kupffer cells, and its absence in absorptive cells also raises the possibility that this enzyme may be related to certain aspects of iron storing process. |
| | |
Authors:
|
M Aoki; M Ito; M Tavassoli |
Related Documents
:
|
16546253 - Intracellular-produced hydroxyl radical mediates h2o2-induced ca2+ influx and cell deat... 2984253 - Role of transferrin, fe, and transferrin receptors in myeloid leukemia cell growth. stu... 21618723 - Cfd-aided cell settler design optimization and scale-up: effect of geometric design and... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Cell and tissue research Volume: 236 ISSN: 0302-766X ISO Abbreviation: Cell Tissue Res. Publication Date: 1984 |
Date Detail:
|
Created Date: 1984-10-19 Completed Date: 1984-10-19 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0417625 Medline TA: Cell Tissue Res Country: GERMANY, WEST |
Other Details:
|
Languages: eng Pagination: 685-92 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Duodenum / analysis*, enzymology, ultrastructure Intestinal Mucosa / analysis*, ultrastructure Iron / analysis* Macrophages / analysis Male Peroxidases / analysis Rats Rats, Inbred Strains |
| Grant Support | |
ID/Acronym/Agency:
|
AM-30142/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
7439-89-6/Iron; EC 1.11.1.-/Peroxidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Synaptic organization of a multifunctional interneuron in the central nervous system of Helix pomati...
Next Document: Administration of caerulein to rats promotes antral epithelial cell renewal.