| Cellular structural biology. | |
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MedLine Citation:
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PMID: 20801639 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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While we appreciate the complexity of the intracellular environment as a general property of every living organism, we collectively lack the appropriate tools to analyze protein structures in a cellular context. In-cell NMR spectroscopy represents a novel biophysical tool to investigate the conformational and functional characteristics of biomolecules at the atomic level inside live cells. Here, we review recent in-cell NMR developments and provide an outlook towards future applications in prokaryotic and eukaryotic cells. We hope to thereby emphasize the usefulness of in-cell NMR techniques for cellular studies of complex biological processes and for structural analyses in native environments. |
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Authors:
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Yutaka Ito; Philipp Selenko |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Current opinion in structural biology Volume: 20 ISSN: 1879-033X ISO Abbreviation: Curr. Opin. Struct. Biol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107784 Medline TA: Curr Opin Struct Biol Country: England |
Other Details:
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Languages: eng Pagination: 640-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Tokyo Metropolitan University, Department of Chemistry, Minami-Osawa, Hachioji, Tokyo 192-0397, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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