Document Detail


Cellular-specific role of toll-like receptor 4 in hepatic ischemia-reperfusion injury in mice.
MedLine Citation:
PMID:  23460269     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: These results provide insight into the individual cellular response of TLR4. The parenchymal HC is an active participant in sterile inflammatory response after I/R through TLR4-mediated activation of proinflammatory signaling and release of danger signals, such as HMGB1.
Authors:
Gary W Nace; Hai Huang; John R Klune; Raymond E Eid; Brian R Rosborough; Sebastian Korff; Shen Li; Richard A Shapiro; Donna B Stolz; Chhinder P Sodhi; David J Hackam; David A Geller; Timothy R Billiar; Allan Tsung
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-05-27
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  58     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-26     Completed Date:  2013-08-30     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  374-87     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Association for the Study of Liver Diseases.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dendritic Cells / immunology
HMGB1 Protein / secretion
Hepatocytes / immunology*
Immunity, Innate / physiology*
JNK Mitogen-Activated Protein Kinases / metabolism
Kupffer Cells / immunology
Liver / immunology*
Male
Mice
Mice, Knockout
Myeloid Cells / immunology
Reperfusion Injury / immunology*
Toll-Like Receptor 4 / deficiency,  physiology*
p38 Mitogen-Activated Protein Kinases / metabolism
Grant Support
ID/Acronym/Agency:
P50 GM053789/GM/NIGMS NIH HHS; R01 DK083752/DK/NIDDK NIH HHS; R01 GM050441/GM/NIGMS NIH HHS; R01 GM078238/GM/NIGMS NIH HHS; R01 GM095566/GM/NIGMS NIH HHS; R01-GM50441/GM/NIGMS NIH HHS; R01-GM95566/GM/NIGMS NIH HHS; T32 AI074490/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/HMGB1 Protein; 0/HMGB1 protein, mouse; 0/Tlr4 protein, mouse; 0/Toll-Like Receptor 4; EC 2.7.11.24/JNK Mitogen-Activated Protein Kinases; EC 2.7.11.24/p38 Mitogen-Activated Protein Kinases
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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