| Cellular senescence: when bad things happen to good cells. | |
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MedLine Citation:
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PMID: 17667954 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cells continually experience stress and damage from exogenous and endogenous sources, and their responses range from complete recovery to cell death. Proliferating cells can initiate an additional response by adopting a state of permanent cell-cycle arrest that is termed cellular senescence. Understanding the causes and consequences of cellular senescence has provided novel insights into how cells react to stress, especially genotoxic stress, and how this cellular response can affect complex organismal processes such as the development of cancer and ageing. |
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Authors:
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Judith Campisi; Fabrizio d'Adda di Fagagna |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Nature reviews. Molecular cell biology Volume: 8 ISSN: 1471-0080 ISO Abbreviation: Nat. Rev. Mol. Cell Biol. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-24 Completed Date: 2007-10-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100962782 Medline TA: Nat Rev Mol Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 729-40 Citation Subset: IM |
Affiliation:
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Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, California 94720, USA. jcampisi@lbl.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging* Animals Cell Aging / physiology* Cell Cycle DNA Damage Humans Neoplasms / etiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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