Document Detail


Cellular reprogramming during mouse development.
MedLine Citation:
PMID:  22918813     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
States of terminal cell differentiation are often considered to be fixed. There are examples, however, in which cells of one type can be converted to a completely different cell type. The process whereby one cell type can be converted to another is referred to as cellular reprogramming. Cellular reprogramming is also referred to in the literature as transdifferentiation (or the direct conversion of one cell type to another without dedifferentiation to an intermediate cell type). Where the conversion between cell types occurs in the developing embryo, the process is referred to as transdetermination. Herein we examine some well-defined examples of transdetermination. Defining the molecular and cellular basis of transdetermination will help us to understand the normal developmental biology of the cells that interconvert, as well as identifying key regulatory transcription factors (master switch genes) that may be important for the reprogramming of stem cells. Harnessing the therapeutic potential of reprogramming and master genes is an important goal in regenerative medicine.
Authors:
Zoë D Burke; Gabriela Miron-Buchacra; David Tosh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Results and problems in cell differentiation     Volume:  55     ISSN:  0080-1844     ISO Abbreviation:  Results Probl Cell Differ     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173555     Medline TA:  Results Probl Cell Differ     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  291-302     Citation Subset:  IM    
Affiliation:
Department of Biology and Biochemistry, Centre for Regenerative Medicine, University of Bath, Claverton Down, Bath, BA2 7AY, UK, Z.D.Burke@bath.ac.uk.
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