Document Detail

Cellular replication and aging.
MedLine Citation:
PMID:  374899     Owner:  NLM     Status:  MEDLINE    
Controversy exists concerning the effect of aging on replicating cell systems. This review summarizes a number of studies which indicate that both in vivo and in vitro, cell replication is significantly altered during aging. In vitro, studies of both human lymphocytes and fibroblasts indicated that a number of replication kinetic parameters are influenced by the age of the cell donor. In vivo, the application of the bromodeoxyuridine-(BrdU)-differential chromatid staining techniques to the analysis of cellular replication kinetics has permitted us to demonstrate that cellular replication is also significantly diminished with aging in mouse and rat cell populations. Therefore, both in vivo and in vitro in human as well as rodent cell populations, the rates of cellular replication are significantly decreased with cellular aging.
E L Schneider; H Sternberg; R R Tice; G C Senula; D Kram; J R Smith; G Bynum
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Mechanisms of ageing and development     Volume:  9     ISSN:  0047-6374     ISO Abbreviation:  Mech. Ageing Dev.     Publication Date:  1979 Feb 
Date Detail:
Created Date:  1979-07-16     Completed Date:  1979-07-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0347227     Medline TA:  Mech Ageing Dev     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  313-24     Citation Subset:  IM    
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MeSH Terms
Bromodeoxyuridine / metabolism
Cell Division*
Cell Survival*
Cells, Cultured
Chromosomes / metabolism
Cytological Techniques
DNA / biosynthesis
Fibroblasts / cytology
Lymphocytes / cytology
Reg. No./Substance:
59-14-3/Bromodeoxyuridine; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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