Document Detail


Cellular replacement and regenerative medicine therapies in ischemic stroke.
MedLine Citation:
PMID:  22594330     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Worldwide, tissue engineering and cellular replacement therapies are at the forefront of the regenerative medicine agenda, and researchers are addressing key diseases, including diabetes, stroke and neurological disorders. It is becoming evident that neurological cell therapy is a necessarily complex endeavor. The brain as a cellular environment is complex, with diverse cell populations, including specialized neurons (e.g., dopaminergic, motor and glutamatergic neurons), each with specific functions. The population also contains glial cells (astrocytes and oligodendrocytes) that offer the supportive network for neuronal function. Neurological disorders have wide and varied pathologies; they can affect predominantly one cell type or a multitude of cell types, which is the case for ischemic stroke. Both neuronal and glial cells are affected by stroke and, depending on the region of the brain affected, different specialized cells are influenced. This review will address currently available therapies and focus on the application and potential of cell replacement, including stem cells and immortalized cell line-derived neurons as regenerative therapies for ischemic stroke, addressing current advances and challenges ahead.
Authors:
John W Thwaites; Vikash Reebye; Paul Mintz; Natasa Levicar; Nagy Habib
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Regenerative medicine     Volume:  7     ISSN:  1746-076X     ISO Abbreviation:  Regen Med     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-18     Completed Date:  2012-09-12     Revised Date:  2013-02-11    
Medline Journal Info:
Nlm Unique ID:  101278116     Medline TA:  Regen Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  387-95     Citation Subset:  IM    
Affiliation:
Advanced Centre for Biochemical Engineering, University College London, Torrington Place, London WC1E 7JE, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Ischemia / complications*,  therapy*
Humans
Neurons / cytology
Nuclear Reprogramming
Regenerative Medicine / methods*
Stem Cell Transplantation / methods*
Stroke / complications*,  therapy*
Comments/Corrections
Erratum In:
Regen Med. 2013 Jan;8(1):92

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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