| Cellular repair strategies for spinal cord injury. | |
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MedLine Citation:
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PMID: 16805705 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The implantation of exogenous cells or tissues has been a popular and successful strategy to overcome physical discontinuity and support axon growth in experimental models of spinal cord injury (SCI). Cellular therapies exhibit a multifarious potential for SCI restoration, providing not only a supportive substrate upon which axons can traverse the injury site, but also reducing progressive tissue damage and scarring, facilitating remyelination repair, and acting as a source for replacing and re-establishing lost neural tissue and its circuitry. The past two decades of research into cell therapies for SCI repair have seen the progressive evolution from whole tissue strategies, such as peripheral nerve grafts, to the use of specific, purified cell types from a diverse range of sources and, recently, to the employment of stem or neural precursor cell populations that have the potential to form a full complement of neural cell types. Although the progression of cell therapies from laboratory to clinical implementation has been slow, human SCI safety and efficacy trials involving several cell types within the US appear to be close at hand. |
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Authors:
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Damien D Pearse; David J Barakat |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert opinion on biological therapy Volume: 6 ISSN: 1744-7682 ISO Abbreviation: Expert Opin Biol Ther Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-06-29 Completed Date: 2006-07-20 Revised Date: 2008-04-14 |
Medline Journal Info:
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Nlm Unique ID: 101125414 Medline TA: Expert Opin Biol Ther Country: England |
Other Details:
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Languages: eng Pagination: 639-52 Citation Subset: IM |
Affiliation:
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University of Miami Miller School of Medicine, The Miami Project to Cure Paralysis, Department of Neurological Surgery, Lois Pope Life Center, 1095 NW 14th Terrace (R-48), Miami, FL 33136, USA. dpearse@miamiproject.med.miami.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Bone Marrow Transplantation / methods*, trends Cell Transplantation / methods*, trends Humans Spinal Cord Injuries / therapy* Tissue and Organ Harvesting / methods |
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