Document Detail


Cellular regulation of prostaglandin H synthase catalysis.
MedLine Citation:
PMID:  9688529     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prostanoids are a group of potent bioactive lipids produced by oxygenation of arachidonate or one of several related polyunsaturated fatty acids. Cellular prostaglandin biosynthesis is tightly regulated, with a large part of the control exerted at the level of cyclooxygenase catalysis by prostaglandin H synthase (PGHS). The two known isoforms of PGHS have been assigned distinct pathophysiological functions, and their cyclooxygenase activities are subject to differential cellular control. This review considers the contributions to cellular catalytic control of the two PGHS isoforms by intracellular compartmentation, accessory proteins, arachidonate levels, and availability of hydroperoxide activator.
Authors:
R J Kulmacz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  FEBS letters     Volume:  430     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-08-13     Completed Date:  1998-08-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  154-7     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University of Texas Health Science Center at Houston, 77030, USA. kulmacz@heart.med.uth.tmc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Catalysis
Isoenzymes / chemistry
Models, Chemical
Prostaglandin-Endoperoxide Synthases / chemistry*
Grant Support
ID/Acronym/Agency:
GM 52170/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Isoenzymes; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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