Document Detail

Cellular regulation of prostaglandin H synthase catalysis.
MedLine Citation:
PMID:  9688529     Owner:  NLM     Status:  MEDLINE    
Prostanoids are a group of potent bioactive lipids produced by oxygenation of arachidonate or one of several related polyunsaturated fatty acids. Cellular prostaglandin biosynthesis is tightly regulated, with a large part of the control exerted at the level of cyclooxygenase catalysis by prostaglandin H synthase (PGHS). The two known isoforms of PGHS have been assigned distinct pathophysiological functions, and their cyclooxygenase activities are subject to differential cellular control. This review considers the contributions to cellular catalytic control of the two PGHS isoforms by intracellular compartmentation, accessory proteins, arachidonate levels, and availability of hydroperoxide activator.
R J Kulmacz
Related Documents :
6842489 - Intraarticular hyaluronic acid injection and synovial prostaglandins in experimental im...
6801999 - Unsaturated fatty acids and cyclooxygenase inhibitors: effects on pial arterioles.
6441529 - Inhibition of prostaglandin action and bone resorption by copper.
10401729 - Nicotinic acid and pyridoxine modulate arachidonic acid metabolism in vitro and ex vivo...
809819 - Inhibition of prostaglandin synthetase and carrageenan-induced edema by tricyclic analo...
441519 - Antagonistic effects of prostaglandin e1 and nicotinic acid on the human fat cell adeny...
16563639 - Neuroprotection of rat hippocampal slices exposed to oxygen-glucose deprivation by enri...
881299 - Effects of high intake of vitamin c by the guinea pigs in pregnancy and lactation on th...
8517859 - Kinetics of the inhibition of tumour growth in mice by eicosapentaenoic acid-reversal b...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  FEBS letters     Volume:  430     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-08-13     Completed Date:  1998-08-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  154-7     Citation Subset:  IM    
Department of Internal Medicine, University of Texas Health Science Center at Houston, 77030, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Isoenzymes / chemistry
Models, Chemical
Prostaglandin-Endoperoxide Synthases / chemistry*
Grant Support
Reg. No./Substance:
0/Isoenzymes; EC Synthases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Origins of globular structure in proteins.
Next Document:  Mapping of MCP-1 functional domains by peptide analysis and site-directed mutagenesis.