| Cellular reaction to group A beta-haemolytic streptococcal membrane antigen and its relation to complement levels in patients with rheumatic heart disease. | |
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MedLine Citation:
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PMID: 329944 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cell-mediated immunity and blood complement activities were studied in 35 patients with chronic rheumatic heart disease (RHD) and 17 normal subjects. The T-cell population in patients with RHD was reduced, as were the CH50 and C3 complement levels. The response to phytohaemagglutinin stimulation was deficient, but the lymphocytes of patients with RHD showed increased avidity for 3H-thymidine when stimulated with specific streptococcal membrane antigen. No differences were found between patients with acute rheumatic activity and those without such activity. The susceptibility of individual patients may be related to the specific sensitisation of lymphocytes, while the fact that this persisted even when T-cell numbers had returned to normal may account for the well-known recrudescenses after streptococcal infections in these patients. |
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Authors:
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R P Sapru; N K Ganguly; S Sharma; R E Chandani; A K Gupta |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British medical journal Volume: 2 ISSN: 0007-1447 ISO Abbreviation: Br Med J Publication Date: 1977 Aug |
Date Detail:
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Created Date: 1977-10-28 Completed Date: 1977-10-28 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372673 Medline TA: Br Med J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 422-4 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, Bacterial
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administration & dosage Chronic Disease Complement C3 / analysis Complement System Proteins / analysis* Humans Immunity, Cellular* Leukocyte Count Lymphocyte Activation Rheumatic Heart Disease / immunology* Streptococcus pyogenes / immunology T-Lymphocytes* / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Bacterial; 0/Complement C3; 9007-36-7/Complement System Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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