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Cellular quiescence caused by the Mdm2 inhibitor nutlin-3A.
MedLine Citation:
PMID:  19855165     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Cellular senescence is characterized by irreversible loss of proliferative potential and a large, flat cell morphology. Ectopic p21 and doxorubicin induced cellular senescence in HT1080 and WI-38-tert cell lines. In the same cell lines, the Mdm2 inhibitor nutlin-3a induced p53 but, unexpectedly, caused quiescence (reversible arrest) with a small cell morphology. We discuss that Mdm antagonists could be used in combination with chemotherapy to reversibly arrest normal cells, thus protecting them during chemotherapy of cancer (cyclotherapy).
Authors:
Lioubov G Korotchkina; Zoya N Demidenko; Andrei V Gudkov; Mikhail V Blagosklonny
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Publication Detail:
Type:  Journal Article     Date:  2009-11-23
Journal Detail:
Title:  Cell cycle (Georgetown, Tex.)     Volume:  8     ISSN:  1551-4005     ISO Abbreviation:  Cell Cycle     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137841     Medline TA:  Cell Cycle     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3777-81     Citation Subset:  IM    
Affiliation:
Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, Buffalo, NY, USA. Blagosklonny@oncotarget.com
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Comment In:
Cell Cycle. 2009 Nov 15;8(22):3634-5   [PMID:  19875921 ]

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