| Cellular protein differences between nontumorigenic Ad5 and tumorigenic Ad12 transformed mouse cells. | |
| | |
MedLine Citation:
|
PMID: 3727404 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Murine fibroblasts transformed by adenovirus 12 (Ad12) show reduced class I major histocompatibility complex (MHC) antigen synthesis and form tumors in syngeneic mice whereas those transformed by adenovirus 5 (Ad5) show no alteration in class I antigen synthesis and do not form tumors (K. B. Eager, J. Williams, D. Breiding, S. Pan, B. Knowles, E. Appella, and R. P. Ricciardi (1985) Proc. Natl. Acad. Sci. USA 82, 5525-5529). Nearly 1500 metabolically labeled polypeptides from the Ad5 and Ad12 transformed cell lines as well as polypeptides from a nontransformed murine line of the same haplotype were compared by two-dimensional gel electrophoresis. In addition to the reduction of the class I H-2 transplantation antigens seen in the Ad12-transformed lines, we detect few but reproducible polypeptide differences between the tumorigenic and nontumorigenic cell lines. |
| | |
Authors:
|
K B Eager; J A Sawicki; R P Ricciardi |
Related Documents
:
|
56444 - Comparison of histocompatibility antigens on cultured human tumor cells and fibroblasts... 3932184 - Expression of rh0(d) antigen in choriocarcinoma of the uterus in an rh0(d)-negative pat... 8044834 - Frequency analysis of tumor-reactive cytotoxic t lymphocytes in peripheral blood of a m... 19184004 - Amyloid precursor-like protein 2 association with hla class i molecules. 11191054 - Role of the tumor microenvironment in mediating response to anti-angiogenic therapy. 19074854 - Overexpression of the dual specificity phosphatase, cdc25c, confers sensitivity on tumo... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Virology Volume: 152 ISSN: 0042-6822 ISO Abbreviation: Virology Publication Date: 1986 Jul |
Date Detail:
|
Created Date: 1986-08-14 Completed Date: 1986-08-14 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0110674 Medline TA: Virology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 487-91 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenoviridae* Animals Cell Transformation, Neoplastic* Cell Transformation, Viral* Electrophoresis, Polyacrylamide Gel Haploidy Histocompatibility Antigens* Mice Molecular Weight |
| Grant Support | |
ID/Acronym/Agency:
|
CA-09171/CA/NCI NIH HHS; CA-29797/CA/NCI NIH HHS; HD-GM-16760/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Histocompatibility Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Nucleotide sequence at the 3' end of Japanese encephalitis virus genomic RNA.
Next Document: Specific labelling of ganglion cells in the cat retina by a monoclonal antibody.