| Cellular proliferation, cell death, and liver histology in Gambusia affinis after dietary exposure to benzidine and 2-aminofluorene. | |
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MedLine Citation:
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PMID: 20448257 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic exposure to arylamines through diet and/or smoking has been associated with genetic changes and tumorigenesis. Cellular proliferation, apoptosis, and histological changes in liver tissue were investigated in Gambusia affinis (G affinis) after chronic dietary exposure to 6.9 mM and 0.069 mM concentrations of benzidine (BZ), 2-aminofluorene (2AF), and their combination for 4, 8, and 12 weeks, respectively. The proliferation assay indicated non-dose-dependent increases in cellular proliferation over the controls for all treatment groups at 4 and 12 weeks but not at 8 weeks except for the low dose of 2AF. The apoptosis assay showed effects in the low-dose group of 2AF and BZ at 4 weeks only. Hematoxylin/eosin staining of liver tissue revealed an increase in oval/spindle cell proliferation and altered foci formation in the treated groups compared with controls. These results demonstrate a mammalian-like response to 2AF and BZ in G affinis liver. |
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Authors:
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Susan Lentz; Rob Eversole; J McHugh Law; Jay C Means |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: International journal of toxicology Volume: 29 ISSN: 1092-874X ISO Abbreviation: Int. J. Toxicol. Publication Date: 2010 May-Jun |
Date Detail:
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Created Date: 2010-05-07 Completed Date: 2010-08-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9708436 Medline TA: Int J Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 247-58 Citation Subset: IM |
Affiliation:
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Western Michigan University, Kalamazoo, MI, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Animals Benzidines / administration & dosage, toxicity* Carcinogenicity Tests / methods Carcinogens / administration & dosage, toxicity* Cell Death / drug effects* Cell Proliferation / drug effects* Cyprinodontiformes* Diet Dose-Response Relationship, Drug Fluorenes / administration & dosage, toxicity* In Situ Nick-End Labeling Liver / drug effects, metabolism, pathology* Male Models, Animal Proliferating Cell Nuclear Antigen / metabolism Random Allocation Statistics, Nonparametric Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Benzidines; 0/Carcinogens; 0/Fluorenes; 0/Proliferating Cell Nuclear Antigen; 153-78-6/2-aminofluorene; 92-87-5/benzidine |
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