| Cellular prion protein participates in amyloid-β transcytosis across the blood-brain barrier. | |
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MedLine Citation:
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PMID: 22293988 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The blood-brain barrier (BBB) facilitates amyloid-β (Aβ) exchange between the blood and the brain. Here, we found that the cellular prion protein (PrP(c)), a putative receptor implicated in mediating Aβ neurotoxicity in Alzheimer's disease (AD), participates in Aβ transcytosis across the BBB. Using an in vitro BBB model, [(125)I]-Aβ(1-40) transcytosis was reduced by genetic knockout of PrP(c) or after addition of a competing PrP(c)-specific antibody. Furthermore, we provide evidence that PrP(c) is expressed in endothelial cells and, that monomeric Aβ(1-40) binds to PrP(c). These observations provide new mechanistic insights into the role of PrP(c) in AD.Journal of Cerebral Blood Flow & Metabolism advance online publication, 1 February 2012; doi:10.1038/jcbfm.2012.7. |
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Authors:
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Thorsten Pflanzner; Benjamin Petsch; Bettina André-Dohmen; Andreas Müller-Schiffmann; Sabrina Tschickardt; Sascha Weggen; Lothar Stitz; Carsten Korth; Claus U Pietrzik |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-01 |
Journal Detail:
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Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: - ISSN: 1559-7016 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Molecular Neurodegeneration, Institute of Pathobiochemistry, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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