Document Detail


Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease.
MedLine Citation:
PMID:  22580107     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We review the cellular and physiological mechanisms responsible for the regulation of blood flow in the retina and choroid in health and disease. Due to the intrinsic light sensitivity of the retina and the direct visual accessibility of fundus blood vessels, the eye offers unique opportunities for the non-invasive investigation of mechanisms of blood flow regulation. The ability of the retinal vasculature to regulate its blood flow is contrasted with the far more restricted ability of the choroidal circulation to regulate its blood flow by virtue of the absence of glial cells, the markedly reduced pericyte ensheathment of the choroidal vasculature, and the lack of intermediate filaments in choroidal pericytes. We review the cellular and molecular components of the neurovascular unit in the retina and choroid, techniques for monitoring retinal and choroidal blood flow, responses of the retinal and choroidal circulation to light stimulation, the role of capillaries, astrocytes and pericytes in regulating blood flow, putative signaling mechanisms mediating neurovascular coupling in the retina, and changes that occur in the retinal and choroidal circulation during diabetic retinopathy, age-related macular degeneration, glaucoma, and Alzheimer's disease. We close by discussing issues that remain to be explored.
Authors:
Joanna Kur; Eric A Newman; Tailoi Chan-Ling
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-05-03
Journal Detail:
Title:  Progress in retinal and eye research     Volume:  31     ISSN:  1873-1635     ISO Abbreviation:  Prog Retin Eye Res     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-07-16     Completed Date:  2012-10-04     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  9431859     Medline TA:  Prog Retin Eye Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  377-406     Citation Subset:  IM    
Copyright Information:
Crown Copyright © 2012. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Calcium / metabolism
Choroid / blood supply*,  innervation,  radiation effects
Eye Diseases / physiopathology*
Humans
Light
Medical Illustration
Oculomotor Muscles / metabolism
Potassium / metabolism
Regional Blood Flow / physiology,  radiation effects
Retina / physiology*,  radiation effects
Retinal Vessels / physiology*,  physiopathology
Signal Transduction / physiology
Visual Fields / physiology
Grant Support
ID/Acronym/Agency:
EY004077/EY/NEI NIH HHS; P30 EY011374/EY/NEI NIH HHS; R01 EY004077/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
7440-09-7/Potassium; 7440-70-2/Calcium
Comments/Corrections

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