| Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease. | |
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MedLine Citation:
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PMID: 22580107 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We review the cellular and physiological mechanisms responsible for the regulation of blood flow in the retina and choroid in health and disease. Due to the intrinsic light sensitivity of the retina and the direct visual accessibility of fundus blood vessels, the eye offers unique opportunities for the non-invasive investigation of mechanisms of blood flow regulation. The ability of the retinal vasculature to regulate its blood flow is contrasted with the far more restricted ability of the choroidal circulation to regulate its blood flow by virtue of the absence of glial cells, the markedly reduced pericyte ensheathment of the choroidal vasculature, and the lack of intermediate filaments in choroidal pericytes. We review the cellular and molecular components of the neurovascular unit in the retina and choroid, techniques for monitoring retinal and choroidal blood flow, responses of the retinal and choroidal circulation to light stimulation, the role of capillaries, astrocytes and pericytes in regulating blood flow, putative signaling mechanisms mediating neurovascular coupling in the retina, and changes that occur in the retinal and choroidal circulation during diabetic retinopathy, age-related macular degeneration, glaucoma, and Alzheimer's disease. We close by discussing issues that remain to be explored. |
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Authors:
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Joanna Kur; Eric A Newman; Tailoi Chan-Ling |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2012-05-03 |
Journal Detail:
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Title: Progress in retinal and eye research Volume: 31 ISSN: 1873-1635 ISO Abbreviation: Prog Retin Eye Res Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-07-16 Completed Date: 2012-10-04 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9431859 Medline TA: Prog Retin Eye Res Country: England |
Other Details:
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Languages: eng Pagination: 377-406 Citation Subset: IM |
Copyright Information:
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Crown Copyright © 2012. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / metabolism Choroid / blood supply*, innervation, radiation effects Eye Diseases / physiopathology* Humans Light Medical Illustration Oculomotor Muscles / metabolism Potassium / metabolism Regional Blood Flow / physiology, radiation effects Retina / physiology*, radiation effects Retinal Vessels / physiology*, physiopathology Signal Transduction / physiology Visual Fields / physiology |
| Grant Support | |
ID/Acronym/Agency:
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EY004077/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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7440-09-7/Potassium; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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