Document Detail


Cellular pathways for transport and efflux of ascorbate and dehydroascorbate.
MedLine Citation:
PMID:  20494648     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mechanisms allowing the cellular transport of ascorbic acid represent a primary aspect for the understanding of the roles played by this vitamin in pathophysiology. Considerable research effort has been spent in the field, on several animal models and different cell types. Several mechanisms have been described to date, mediating the movements of different redox forms of ascorbic acid across cell membranes. Vitamin C can enter cells both in its reduced and oxidized form, ascorbic acid (AA) and dehydroascorbate (DHA), utilizing respectively sodium-dependent transporters (SVCT) or glucose transporters (GLUT). Modulation of SVCT expression and function has been described by cytokines, steroids and post-translational protein modification. Cellular uptake of DHA is followed by its intracellular reduction to AA by several enzymatic and non-enzymatic systems. Efflux of vitamin C has been also described in a number of cell types and different pathophysiological functions were proposed for this phenomenon, in dependence of the cell model studied. Cellular efflux of AA is mediated through volume-sensitive (VSOAC) and Ca(2+)-dependent anion channels, gap-junction hemichannels, exocytosis of secretory vesicles and possibly through homo- and hetero-exchange systems at the plasma membrane level. Altogether, available data suggest that cellular efflux of ascorbic acid - besides its uptake - should be taken into account when evaluating the cellular homeostasis and functions of this important vitamin.
Authors:
Alessandro Corti; Alessandro F Casini; Alfonso Pompella
Related Documents :
8439008 - Ascorbate and dehydroascorbate measurements in aqueous solutions and plasma determined ...
14962048 - Morphological and physiological changes of staphylococcus aureus exposed to hypochlorou...
3855878 - Study of ascorbate status in murine and human leukaemias.
18389008 - Pyomelanin is produced by shewanella algae bry and affected by exogenous iron.
9843728 - K+ current inhibition by amphiphilic fatty acid metabolites in rat ventricular myocytes.
11132178 - Fatty acid chain length and degree of unsaturation are inversely associated with serum ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-05-28
Journal Detail:
Title:  Archives of biochemistry and biophysics     Volume:  500     ISSN:  1096-0384     ISO Abbreviation:  Arch. Biochem. Biophys.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-14     Completed Date:  2010-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372430     Medline TA:  Arch Biochem Biophys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  107-15     Citation Subset:  IM    
Copyright Information:
2010 Elsevier Inc. All rights reserved.
Affiliation:
Dipartimento di Patologia Sperimentale, Università di Pisa, Italy. a.corti@biomed.unipi.it
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Ascorbic Acid / chemistry,  metabolism*,  pharmacology
Biological Transport, Active
Cell Membrane / metabolism
Dehydroascorbic Acid / chemistry,  metabolism*
Glucose Transport Proteins, Facilitative / metabolism
Humans
Ion Channels / metabolism
Models, Biological
Neoplasms / drug therapy,  metabolism
Organic Anion Transporters, Sodium-Dependent / metabolism
Oxidation-Reduction
Symporters / metabolism
Chemical
Reg. No./Substance:
0/Glucose Transport Proteins, Facilitative; 0/Ion Channels; 0/Organic Anion Transporters, Sodium-Dependent; 0/Symporters; 490-83-5/Dehydroascorbic Acid; 50-81-7/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  dynamics of zeaxanthin binding to the photosystem ii monomeric antenna protein lhcb6 (cp24) and modu...
Next Document:  Phytoestrogen consumption and association with breast, prostate and colorectal cancer in EPIC Norfol...