Document Detail

Cellular pathways for transport and efflux of ascorbate and dehydroascorbate.
MedLine Citation:
PMID:  20494648     Owner:  NLM     Status:  MEDLINE    
The mechanisms allowing the cellular transport of ascorbic acid represent a primary aspect for the understanding of the roles played by this vitamin in pathophysiology. Considerable research effort has been spent in the field, on several animal models and different cell types. Several mechanisms have been described to date, mediating the movements of different redox forms of ascorbic acid across cell membranes. Vitamin C can enter cells both in its reduced and oxidized form, ascorbic acid (AA) and dehydroascorbate (DHA), utilizing respectively sodium-dependent transporters (SVCT) or glucose transporters (GLUT). Modulation of SVCT expression and function has been described by cytokines, steroids and post-translational protein modification. Cellular uptake of DHA is followed by its intracellular reduction to AA by several enzymatic and non-enzymatic systems. Efflux of vitamin C has been also described in a number of cell types and different pathophysiological functions were proposed for this phenomenon, in dependence of the cell model studied. Cellular efflux of AA is mediated through volume-sensitive (VSOAC) and Ca(2+)-dependent anion channels, gap-junction hemichannels, exocytosis of secretory vesicles and possibly through homo- and hetero-exchange systems at the plasma membrane level. Altogether, available data suggest that cellular efflux of ascorbic acid - besides its uptake - should be taken into account when evaluating the cellular homeostasis and functions of this important vitamin.
Alessandro Corti; Alessandro F Casini; Alfonso Pompella
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-05-28
Journal Detail:
Title:  Archives of biochemistry and biophysics     Volume:  500     ISSN:  1096-0384     ISO Abbreviation:  Arch. Biochem. Biophys.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-14     Completed Date:  2010-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372430     Medline TA:  Arch Biochem Biophys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  107-15     Citation Subset:  IM    
Copyright Information:
2010 Elsevier Inc. All rights reserved.
Dipartimento di Patologia Sperimentale, Università di Pisa, Italy.
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MeSH Terms
Ascorbic Acid / chemistry,  metabolism*,  pharmacology
Biological Transport, Active
Cell Membrane / metabolism
Dehydroascorbic Acid / chemistry,  metabolism*
Glucose Transport Proteins, Facilitative / metabolism
Ion Channels / metabolism
Models, Biological
Neoplasms / drug therapy,  metabolism
Organic Anion Transporters, Sodium-Dependent / metabolism
Symporters / metabolism
Reg. No./Substance:
0/Glucose Transport Proteins, Facilitative; 0/Ion Channels; 0/Organic Anion Transporters, Sodium-Dependent; 0/Symporters; 490-83-5/Dehydroascorbic Acid; 50-81-7/Ascorbic Acid

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