Document Detail

Cellular pathology of mitral valve prolapse.
MedLine Citation:
PMID:  19375355     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Mitral valve prolapse (MVP) is the most frequent cause of chronic, pure, and isolated mitral regurgitation, and is estimated to affect more than 144 million individuals worldwide. This short review focuses in particular on the structural and cellular aspects of MVP in humans. The key microscopic change in MVP appears to occur in the fibrosa, on which the structural integrity of the entire valve depends. Recent discoveries showed that proteoglycans may play an active role in both MVP initiation and/or progression together with valvular interstitial cells. A full understanding of the cellular basis of MVP goes beyond a mere mechanicistic description of the disease, involving the transformation of resting fibroblasts into activated myofibroblasts.
CONCLUSIONS: Mitral valve could represent therefore an ideal environment to study early transformation phases of fibroblasts toward a protomyofibroblast phenotype.
Marco Prunotto; Philippe Primo Caimmi; Massimo Bongiovanni
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-04-16
Journal Detail:
Title:  Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology     Volume:  19     ISSN:  1879-1336     ISO Abbreviation:  Cardiovasc. Pathol.     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-07-12     Completed Date:  2010-10-14     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  9212060     Medline TA:  Cardiovasc Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e113-7     Citation Subset:  IM    
Pathology and Immunology Department, University of Geneva, Geneva, Switzerland.
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MeSH Terms
Cell Differentiation
Fibroblasts / cytology
Mitral Valve / metabolism,  pathology*
Mitral Valve Prolapse / pathology*
Proteoglycans / metabolism
Reg. No./Substance:

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