Document Detail

Cellular origins of beta-cell regeneration: a legacy view of historical controversies.
MedLine Citation:
PMID:  19765178     Owner:  NLM     Status:  MEDLINE    
Beta-cell regeneration represents a major goal of therapy for diabetes. Unravelling the origin of beta cells during pancreatic regeneration could help restore a functional beta-cell mass in diabetes patients. This scientific question has represented a longstanding interest still intensively investigated today. This review focuses on pioneering observations and subsequent theories made 100 years ago and describes how technical innovation helped resolve some, but not all, of the controversies generated by these early investigators. At the end of the 19th century, complete pancreatectomy demonstrated the crucial physiological role of the pancreas and its link with diabetes. Pancreatic injury models, including pancreatectomy and ductal ligation, allowed investigators to describe islet function and to assess the regenerative capacity of the pancreas. Three main theories were proposed to explain the origins of newly formed islets: (i) transdifferentiation of acinar cells into islets, (ii) islet neogenesis, a process reminiscent of islet formation during embryonic development, and (iii) replication of preexisting islet cells. Despite considerable technical innovation in the last 50 years, the origin of new adult beta cells remains highly controversial and the same three theories are still debated today.
A Granger; J A Kushner
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of internal medicine     Volume:  266     ISSN:  1365-2796     ISO Abbreviation:  J. Intern. Med.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-21     Completed Date:  2009-12-01     Revised Date:  2013-09-10    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  325-38     Citation Subset:  IM    
Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA.
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MeSH Terms
Cell Differentiation / physiology*
Cell Proliferation
Cell Transdifferentiation / physiology
Islets of Langerhans / cytology,  physiology*
Models, Biological*
Pancreas / anatomy & histology,  cytology,  physiology*
Regeneration / physiology*
Grant Support

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