Document Detail


Cellular and molecular mechanisms of cancer cell invasion.
MedLine Citation:
PMID:  21409955     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Cancer malignancy is characterized by cancer cell invasion within local and distant ecosystems. Data from our laboratory are reviewed with a focus on cross-signaling between cancer cells and host cells such as myofibroblasts, mesenchymal stem cells and adipocytes. Invasion-associated cellular activities, namely epithelial to mesenchymal transition, homotypic and heterotypic cell-cell adhesion, cell-matrix adhesion, migration, proteolysis and vesicle exocytosis, depend on branching networks of signal transduction pathways including activation of trimeric G proteins, phosphoinositide 3-kinase, src, signal transducer and activator of transcription and the Rab, Rac and Rho family of small GTPases. The role of proteolysis in invasion is not limited to breakdown of extracellular matrix but also causes cleavage of pro-angiogenic fragments from cell surface glycoproteins. Some cell types or molecules implicated in invasion-associated activities may serve as prognostic biomarker or as target for patient-tailored therapy.
Authors:
O De Wever; L Lapeire; A De Boeck; A Hendrix
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Verhandelingen - Koninklijke Academie voor Geneeskunde van België     Volume:  72     ISSN:  0302-6469     ISO Abbreviation:  Verh. K. Acad. Geneeskd. Belg.     Publication Date:  2010  
Date Detail:
Created Date:  2011-03-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413210     Medline TA:  Verh K Acad Geneeskd Belg     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  309-26     Citation Subset:  IM    
Affiliation:
Laboratory of Experimental Cancer Research, Ghent University Hospital, De Pintelaan, 185-B 9000 Gent.
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