Document Detail

Cellular and molecular interactions of mesenchymal stem cells in innate immunity.
MedLine Citation:
PMID:  23146943     Owner:  NLM     Status:  Publisher    
In recent years, human mesenchymal stem/stromal cells (MSC) have attracted major attention for their possible clinical applications. In addition to their tissue regenerative capacity, they display immune-modulatory properties for which they have been used in the treatment of acute graft-versus-host disease and autoimmune diseases. Various studies have analyzed the inhibitory effect exerted by MSC on cells belonging to acquired or to innate immunity. In this context, MSC have been shown to inhibit proliferation and function of natural killer (NK) cells and to hinder the generation of dendritic cells and macrophages, thus interfering with inflammatory processes and with the generation of type I immune responses. In addition, MSC promote the differentiation of regulatory cells and participate in the regeneration of tissues damaged as a consequence of the inflammatory process. Different molecular mechanisms are involved in the immunosuppressive effect. Further investigation on the biology of MSC and on the regulatory events involved in their functional activities can help to optimize their use in clinical practice.Immunology and Cell Biology advance online publication, 13 November 2012; doi:10.1038/icb.2012.62.
Grazia Maria Spaggiari; Lorenzo Moretta
Related Documents :
25298033 - Differential cellular effects of old and new oral anticoagulants: consequences to the g...
23440593 - Multiplex protein profiling of bronchoalveolar lavage in idiopathic pulmonary fibrosis ...
23836323 - The trefoil factor 1 (tff1) protein involved in doxorubicin‑induced apoptosis resista...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-13
Journal Detail:
Title:  Immunology and cell biology     Volume:  -     ISSN:  1440-1711     ISO Abbreviation:  Immunol. Cell Biol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8706300     Medline TA:  Immunol Cell Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Dipartmento di Medicina Sperimentale, Università degli Studi di Genova, Genova, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Mesenchymal stromal cells and regulatory T cells: the Yin and Yang of peripheral tolerance?
Next Document:  Membrane nanotubes in myeloid cells in the adult mouse cornea represent a novel mode of immune cell ...