| Cellular and molecular actions of Methylene Blue in the nervous system. | |
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MedLine Citation:
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PMID: 19760660 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Methylene Blue (MB), following its introduction to biology in the 19th century by Ehrlich, has found uses in various areas of medicine and biology. At present, MB is the first line of treatment in methemoglobinemias, is used frequently in the treatment of ifosfamide-induced encephalopathy, and is routinely employed as a diagnostic tool in surgical procedures. Furthermore, recent studies suggest that MB has beneficial effects in Alzheimer's disease and memory improvement. Although the modulation of the cGMP pathway is considered the most significant effect of MB, mediating its pharmacological actions, recent studies indicate that it has multiple cellular and molecular targets. In the majority of cases, biological effects and clinical applications of MB are dictated by its unique physicochemical properties including its planar structure, redox chemistry, ionic charges, and light spectrum characteristics. In this review article, these physicochemical features and the actions of MB on multiple cellular and molecular targets are discussed with regard to their relevance to the nervous system. |
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Authors:
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Murat Oz; Dietrich E Lorke; Mohammed Hasan; George A Petroianu |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Medicinal research reviews Volume: 31 ISSN: 1098-1128 ISO Abbreviation: Med Res Rev Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-15 Completed Date: 2011-04-15 Revised Date: 2012-01-04 |
Medline Journal Info:
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Nlm Unique ID: 8103150 Medline TA: Med Res Rev Country: United States |
Other Details:
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Languages: eng Pagination: 93-117 Citation Subset: IM |
Copyright Information:
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© 2009 Wiley Periodicals, Inc. |
Affiliation:
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Integrative Neuroscience Section, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, Maryland 21224, USA. moz@intra.nida.nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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drug therapy* Animals Humans Ifosfamide / adverse effects Methemoglobinemia / drug therapy Methylene Blue / chemistry*, therapeutic use* Neurons / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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NIH0011080950//PHS HHS; Z01 DA000512-01/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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3778-73-2/Ifosfamide; 61-73-4/Methylene Blue |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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