| Cellular- and micro-dosimetry of heterogeneously distributed tritium. | |
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MedLine Citation:
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PMID: 21770699 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Purpose: The assessment of radiotoxicity for heterogeneously distributed tritium should be based on the subcellular dose and relative biological effectiveness (RBE) for cell nucleus. In the present work, geometry-dependent absorbed dose and RBE were calculated using Monte Carlo codes for tritium in the cell, cell surface, cytoplasm, or cell nucleus. Materials and methods: Penelope (PENetration and Energy LOss of Positrins and Electrons) code was used to calculate the geometry-dependent absorbed dose, lineal energy, and electron fluence spectrum. RBE for the intestinal crypt regeneration was calculated using a lineal energy-dependent biological weighting function. RBE for the induction of DNA double strand breaks was estimated using a nucleotide-level map for clustered DNA lesions of the Monte Carlo damage simulation (MCDS) code. Results: For a typical cell of 10 μm radius and 5 μm nuclear radius, tritium in the cell nucleus resulted in much higher RBE-weighted absorbed dose than tritium distributed uniformly. Conversely, tritium distributed on the cell surface led to trivial RBE-weighted absorbed dose due to irradiation geometry and great attenuation of beta particles in the cytoplasm. For tritium uniformly distributed in the cell, the RBE-weighted absorbed dose was larger compared to tritium uniformly distributed in the tissue. Conclusions: Cellular- and micro-dosimetry models were developed for the assessment of heterogeneously distributed tritium. |
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Authors:
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Tsi-Chian Chao; Chun-Ching Wang; Junli Li; Chunyan Li; Chuan-Jong Tung |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-19 |
Journal Detail:
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Title: International journal of radiation biology Volume: - ISSN: 1362-3095 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8809243 Medline TA: Int J Radiat Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Medical Imaging and Radiological Sciences, Chang Gung University , Taoyuan, Taipei , Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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