Document Detail


Cellular metabolism of arsenic studied in mammalian cellsin vitro.
MedLine Citation:
PMID:  24202416     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The cytotoxicity of trivalent and pentavalent inorganic arsenic was studied in cultured mouse fibroblasts. Concentrations of As(III) in the μM range and approximately 10-fold higher concentrations of As(V) led to a reduction of cellular proliferation and viability with a concomitant increase of LDH release and stimulation of lactate production. Cells pretreated with a low As(III) concentration were less sensitive to toxic doses of As(III) or As(V).Uptake of As(III) by the cells was greater than that of As(V). Both forms of inorganic arsenic were converted intracellularly to monomethylarsonic (MMA) and dimethylarsinic (DMA) acids, which were subsequently released into the culture medium. In As-pretreated cells, which proved more resistant to As toxicity, biotransformation of inorganic to MMA and DMA was increased.
Authors:
A B Fischer; J P Buchet; R R Lauwerys
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental geochemistry and health     Volume:  11     ISSN:  0269-4042     ISO Abbreviation:  Environ Geochem Health     Publication Date:  1989 Dec 
Date Detail:
Created Date:  2013-11-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8903118     Medline TA:  Environ Geochem Health     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  87-92     Citation Subset:  -    
Affiliation:
Institute of Hygiene, Justus-Liebig University, Giessen, Federal Republic of Germany.
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