Document Detail

Cellular metabolic stress: considering how cells respond to nutrient excess.
MedLine Citation:
PMID:  20965425     Owner:  NLM     Status:  MEDLINE    
Nutrient stress is generally considered from the standpoint of how cells detect and respond to an insufficient supply of nutrients to meet their bioenergetic needs. However, cells also experience stress as a result of nutrient excess, during which reactive oxygen species (ROS) production exceeds that required for normal physiological responses. This may occur as a result of oncogene activation or chronic exposure to growth factors combined with high levels of nutrients. As a result, multiple mechanisms have evolved to allow cells to detect and adapt to elevated levels of intracellular metabolites, including promotion of signaling and proliferation by ROS, amino acid-dependent mTOR activation, and regulation of signaling and transcription through metabolite-sensitive protein modifications. We discuss how each of these responses can contribute to the development and/or progression of cancer under conditions of cellular nutrient excess and their potential roles in linking chronic organismal over-nutrition (obesity) with cancer.
Kathryn E Wellen; Craig B Thompson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Molecular cell     Volume:  40     ISSN:  1097-4164     ISO Abbreviation:  Mol. Cell     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-22     Completed Date:  2010-12-10     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  9802571     Medline TA:  Mol Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  323-32     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Cell Physiological Processes / physiology*
Cell Proliferation
Energy Metabolism / physiology*
Models, Biological
Neoplasms / metabolism,  pathology,  physiopathology
Reactive Oxygen Species / metabolism
Signal Transduction*
Stress, Physiological / physiology*
Grant Support
R01 CA092660/CA/NCI NIH HHS; R01 CA099179/CA/NCI NIH HHS; R01 CA105463/CA/NCI NIH HHS
Reg. No./Substance:
0/Reactive Oxygen Species

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