| Cellular metabolic stress: considering how cells respond to nutrient excess. | |
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MedLine Citation:
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PMID: 20965425 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nutrient stress is generally considered from the standpoint of how cells detect and respond to an insufficient supply of nutrients to meet their bioenergetic needs. However, cells also experience stress as a result of nutrient excess, during which reactive oxygen species (ROS) production exceeds that required for normal physiological responses. This may occur as a result of oncogene activation or chronic exposure to growth factors combined with high levels of nutrients. As a result, multiple mechanisms have evolved to allow cells to detect and adapt to elevated levels of intracellular metabolites, including promotion of signaling and proliferation by ROS, amino acid-dependent mTOR activation, and regulation of signaling and transcription through metabolite-sensitive protein modifications. We discuss how each of these responses can contribute to the development and/or progression of cancer under conditions of cellular nutrient excess and their potential roles in linking chronic organismal over-nutrition (obesity) with cancer. |
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Authors:
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Kathryn E Wellen; Craig B Thompson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Molecular cell Volume: 40 ISSN: 1097-4164 ISO Abbreviation: Mol. Cell Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-22 Completed Date: 2010-12-10 Revised Date: 2013-05-27 |
Medline Journal Info:
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Nlm Unique ID: 9802571 Medline TA: Mol Cell Country: United States |
Other Details:
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Languages: eng Pagination: 323-32 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Physiological Processes / physiology* Cell Proliferation Energy Metabolism / physiology* Humans Models, Biological Neoplasms / metabolism, pathology, physiopathology Reactive Oxygen Species / metabolism Signal Transduction* Stress, Physiological / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA092660-10/CA/NCI NIH HHS; R01 CA099179-10/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Reactive Oxygen Species |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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