| Cellular mechanisms for direction selectivity in the retina. | |
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MedLine Citation:
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PMID: 17640521 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Direction selectivity represents a fundamental computation found across multiple sensory systems. In the mammalian visual system, direction selectivity appears first in the retina, where excitatory and inhibitory interneurons release neurotransmitter most rapidly during movement in a preferred direction. Two parallel sets of interneuron signals are integrated by a direction-selective ganglion cell, which creates a direction preference for both bright and dark moving objects. Direction selectivity of synaptic input becomes amplified by action potentials in the ganglion cell dendrites. Recent work has elucidated direction-selective mechanisms in inhibitory circuitry, but mechanisms in excitatory circuitry remain unexplained. |
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Authors:
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Jonathan B Demb |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Neuron Volume: 55 ISSN: 0896-6273 ISO Abbreviation: Neuron Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-07-20 Completed Date: 2007-08-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8809320 Medline TA: Neuron Country: United States |
Other Details:
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Languages: eng Pagination: 179-86 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology & Visual Sciences, University of Michigan, Kellogg Eye Center, Ann Arbor, MI 48105, USA. jdemb@umich.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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physiology Amacrine Cells / physiology* Animals Humans Motion Perception / physiology* Retina / cytology*, physiology Retinal Ganglion Cells / physiology* Signal Transduction / physiology Synaptic Transmission / physiology* Visual Pathways / cytology*, physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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