Document Detail

Cellular mechanisms of aminoglycoside ototoxicity.
MedLine Citation:
PMID:  20717031     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: To summarize advances in the study of the interaction between sensory hair cells and aminoglycoside antibiotics.
RECENT FINDINGS: Aminoglycosides enter hair cells through mechanotransduction channels and initiate an active signaling pathway that leads to cell death. Early expression of heat shock proteins can protect hair cells from aminoglycosides, although signaling from surrounding supporting cells appears to promote hair cell death. Studies of certain human deafness mutations have revealed new insights into the role of mitochondria in aminoglycoside ototoxicity.
SUMMARY: The cellular mechanisms of aminoglycoside ototoxicity continue to be an active topic of research and newly developed animal models offer great promise for future advances. Nevertheless, proven clinical methods for the prevention of ototoxic injury are not yet available.
Mark E Warchol
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current opinion in otolaryngology & head and neck surgery     Volume:  18     ISSN:  1531-6998     ISO Abbreviation:  Curr Opin Otolaryngol Head Neck Surg     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-09     Completed Date:  2011-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9417024     Medline TA:  Curr Opin Otolaryngol Head Neck Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  454-8     Citation Subset:  IM    
Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
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MeSH Terms
Aminoglycosides / adverse effects*
Anti-Bacterial Agents / adverse effects*
Hair Cells, Auditory / drug effects*
Grant Support
Reg. No./Substance:
0/Aminoglycosides; 0/Anti-Bacterial Agents

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