| Cellular mRNA expression of the transcription factor NGFI-B suggests a gene regulatory role in striatal opiate-peptide neurons. | |
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MedLine Citation:
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PMID: 11382384 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies have shown that NGFI-B mRNA is highly expressed in the adult striatum. In the present study we analyzed the anatomical distribution of NGFI-B mRNA within this brain region as well as the degree of co-existence of NGFI-B with different striatal markers in the adult brain. NGFI-B mRNA levels were found to be significantly higher within the dorsomedial portion of the striatum as compared to the ventrolateral striatum. This distribution pattern was maintained throughout the rostro--caudal axis of the striatum. Double in situ hybridization studies showed that striatal NGFI-B mRNA colocalized with a subset of preproenkephalin and prodynorphin positive spiny neurons within the dorsomedial striatum; 22--28% of all opiate-peptide positive cells co-expressed NGFI-B mRNA. NGFI-B did not colocalize with striatal aspiny interneurons expressing choline acetyl transferase mRNA or those containing the calcium-binding protein parvalbumin. The pattern of NGFI-B mRNA expression within different striatal spiny projecting neurons suggests that this transcription factor may have a direct effect on the function of different striatal efferent pathways. |
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Authors:
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C Bäckman; B J Hoffer; H Misawa; M Morales |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain research Volume: 903 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-05-30 Completed Date: 2001-08-16 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 26-32 Citation Subset: IM |
Affiliation:
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Cellular Neurophysiology, National Institute on Drug Abuse/NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. cbackman@intra.nida.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Choline O-Acetyltransferase / genetics Corpus Striatum / cytology*, physiology DNA-Binding Proteins / genetics* Dynorphins / genetics, metabolism Enkephalins / genetics, metabolism* Gene Expression Regulation / physiology In Situ Hybridization Interneurons / physiology* Male Nuclear Receptor Subfamily 4, Group A, Member 1 Opioid Peptides / metabolism* Protein Precursors / genetics, metabolism RNA, Messenger / analysis Rats Rats, Sprague-Dawley Receptors, Cytoplasmic and Nuclear Receptors, Steroid Transcription Factors / genetics* |
| Chemical | |
Reg. No./Substance:
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0/DNA-Binding Proteins; 0/Enkephalins; 0/Nr4a1 protein, rat; 0/Nuclear Receptor Subfamily 4, Group A, Member 1; 0/Opioid Peptides; 0/Protein Precursors; 0/RNA, Messenger; 0/Receptors, Cytoplasmic and Nuclear; 0/Receptors, Steroid; 0/Transcription Factors; 0/proenkephalin; 74913-18-1/Dynorphins; EC 2.3.1.6/Choline O-Acetyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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